Unraveling the role of NLRP3 inflammasome in allergic inflammation: implications for novel therapies
Hui-Fei Lu,
Yi-Chi Zhou,
Tian-Yong Hu
et al.
Abstract:Allergic diseases like asthma, allergic rhinitis and dermatitis pose a significant global health burden, driving the search for novel therapies. The NLRP3 inflammasome, a key component of the innate immune system, is implicated in various inflammatory diseases. Upon exposure to allergens, NLRP3 undergoes a two-step activation process (priming and assembly) to form active inflammasomes. These inflammasomes trigger caspase-1 activation, leading to the cleavage of pro-inflammatory cytokines (IL-1β and IL-18) and … Show more
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