Unraveling the role of chitosan for nasal drug delivery systems: A review

Kaur, Gurjeet; Goyal, Jayant; Behera, Prabhat Kumar; Devi, Sushma; Singh, Sachin Kumar; Garg, Varun; Mittal, Neeraj

doi:10.1016/j.carpta.2023.100316

Cited by 8 publications

(3 citation statements)

References 112 publications

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“…Additionally, other crosslinking agents like glutaraldehyde, formaldehyde, and the naturally occurring genipin have been employed for microsphere preparation. Various methods, including coacervation, multiple emulsion, and solvent evaporation, have been utilized for the preparation of chitosan microspheres, allowing for the modification of particle sizes suitable for oral, nasal, and parenteral drug delivery [153,154].…”

Section: Permeation Enhancermentioning

confidence: 99%

Shrimp Waste Upcycling: Unveiling the Potential of Polysaccharides, Proteins, Carotenoids, and Fatty Acids with Emphasis on Extraction Techniques and Bioactive Properties

Rossi,

Grosso,

Delerue-Matos

2024

Marine Drugs

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Shrimp processing generates substantial waste, which is rich in valuable components such as polysaccharides, proteins, carotenoids, and fatty acids. This review provides a comprehensive overview of the valorization of shrimp waste, mainly shrimp shells, focusing on extraction methods, bioactivities, and potential applications of these bioactive compounds. Various extraction techniques, including chemical extraction, microbial fermentation, enzyme-assisted extraction, microwave-assisted extraction, ultrasound-assisted extraction, and pressurized techniques are discussed, highlighting their efficacy in isolating polysaccharides, proteins, carotenoids, and fatty acids from shrimp waste. Additionally, the bioactivities associated with these compounds, such as antioxidant, antimicrobial, anti-inflammatory, and antitumor properties, among others, are elucidated, underscoring their potential in pharmaceutical, nutraceutical, and cosmeceutical applications. Furthermore, the review explores current and potential utilization avenues for these bioactive compounds, emphasizing the importance of sustainable resource management and circular economy principles in maximizing the value of shrimp waste. Overall, this review paper aims to provide insights into the multifaceted aspects of shrimp waste valorization, offering valuable information for researchers, industries, and policymakers interested in sustainable resource utilization and waste-management strategies.

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Section: Permeation Enhancermentioning

confidence: 99%

Shrimp Waste Upcycling: Unveiling the Potential of Polysaccharides, Proteins, Carotenoids, and Fatty Acids with Emphasis on Extraction Techniques and Bioactive Properties

Rossi,

Grosso,

Delerue-Matos

2024

Marine Drugs

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“…According to Kaur et al (2023), nanoscience and technology were used more and more in targeted drug administration to increase therapeutic efficacy and safety over the previous 20 years. Biodegradable polymers, such as those found in CS drug delivery systems, provide an alternative to controlled drug release through the nose.…”

Section: The Potential Challenges Of Utilizing Chitosan and Its Nanof...mentioning

confidence: 99%

Impacts of chitosan and its nanoformulations on the metabolic syndromes: a review

Abd El‐Hack,

Kamal,

Alazragi

et al. 2023

Braz. J. Biol.

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A significant public health issue worldwide is metabolic syndrome, a cluster of metabolic illnesses that comprises insulin resistance, obesity, dyslipidemia, hyperglycemia, and hypertension. The creation of natural treatments and preventions for metabolic syndrome is crucial. Chitosan, along with its nanoformulations, is an oligomer of chitin, the second-most prevalent polymer in nature, which is created via deacetylation. Due to its plentiful biological actions in recent years, chitosan and its nanoformulations have drawn much interest. Recently, the chitosan nanoparticle-based delivery of CRISPR-Cas9 has been applied in treating metabolic syndromes. The benefits of chitosan and its nanoformulations on insulin resistance, obesity, diabetes mellitus, dyslipidemia, hyperglycemia, and hypertension will be outlined in the present review, highlighting potential mechanisms for the avoidance and medication of the metabolic syndromes by chitosan and its nanoformulations.

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“…A challenging topic studied lately has been the intranasal administration of drugs, due to its advantages. Many drug administration systems are based on chitosan or its derivatives, such as gels for the intranasal administration of antihistamines (loratadine and chlorpheniramine) [10]; insulin [11]; liposomes and nanoemulsions for the administration of a derivative of Dehydroepiandrosterone (DHEA) [12]; microemulsion with silymarin for the treatment of Parkinson's disease [13]; nanoparticles with galantamine [14] or ropinirole [15]; and nanocrystals with memantine for the treatment of Alzheimer's disease [16].…”

mentioning

confidence: 99%