Unraveling the rationale and conducting a comprehensive assessment of KD025 (Belumosudil) as a candidate drug for inhibiting adipogenic differentiation—a systematic review

Barbalho, Sandra Maria; de Alvares Goulart, Ricardo; Minniti, Giulia; Bechara, Marcelo Dib; de Castro, Marcela Vialogo Marques; Dias, Jefferson Aparecido; Laurindo, Lucas Fornari

doi:10.1007/s00210-023-02834-6

Naunyn-Schmiedeberg's Arch Pharmacol

2023

DOI: 10.1007/s00210-023-02834-6

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Unraveling the rationale and conducting a comprehensive assessment of KD025 (Belumosudil) as a candidate drug for inhibiting adipogenic differentiation—a systematic review

Sandra Maria Barbalho,

Ricardo de Alvares Goulart,

Giulia Minniti

et al.

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2024

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Cited by 1 publication

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

de Lima,

Tanaka,

Lamas

et al. 2024

Biomedicines

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The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the muscle mass reduction seen in sarcopenia and the decline in neuronal function characteristic of neurodegeneration. Our limited understanding of the intricate relationships within this triad hinders accurate diagnosis and effective treatment strategies. This review analyzes the interrelated mechanisms that contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, and impaired nutrient delivery. The aim is to understand the common pathways involved and to suggest comprehensive therapeutic approaches. Vascular dysfunctions hinder the circulation of blood and the transportation of nutrients, resulting in sarcopenia characterized by muscle atrophy and weakness. Vascular dysfunction and sarcopenia have a negative impact on physical function and quality of life. Neurodegenerative diseases exhibit comparable pathophysiological mechanisms that affect cognitive and motor functions. Preventive and therapeutic approaches encompass lifestyle adjustments, addressing oxidative stress, inflammation, and integrated therapies that focus on improving vascular and muscular well-being. Better understanding of these links can refine therapeutic strategies and yield better patient outcomes. This study emphasizes the complex interplay between vascular dysfunction, muscle degeneration, and cognitive decline, highlighting the necessity for multidisciplinary treatment approaches. Advances in this domain promise improved diagnostic accuracy, more effective therapeutic options, and enhanced preventive measures, all contributing to a higher quality of life for the elderly population.

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

de Lima,

Tanaka,

Lamas

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

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Unraveling the rationale and conducting a comprehensive assessment of KD025 (Belumosudil) as a candidate drug for inhibiting adipogenic differentiation—a systematic review

Cited by 1 publication

References 161 publications

Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

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