Unraveling the Mystery of COVID-19 Postvaccination Myocarditis: A Systematic Review of Current Cases

Ghoshouni, Hamed; Bagherieh, Sara; Parvizinia, Mohammad; Askari, Mozhde; Sadeghi, Masoumeh; Mirmosayyeb, Omid

doi:10.1155/2022/2438913

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Unlike the clinical course of multisystem inflammatory syndrome in children (MIS-C) [12][13][14], in adolescents with suspected myocarditis related to COVID-19 vaccination, data suggest that myocarditis has a mild hospital course, with a quick clinical recovery and excellent middleterm outcomes, as well as a complete resolution without sequelae in adolescents [15]. Furthermore, myocarditis has been associated with other vaccines, such as smallpox [16] and influenza [17,18]. Interestingly, a meta-analysis compared COVID-19-vaccine-related myopericarditis to non-COVID-19-vaccine-related myopericarditis [19].…”

Section: Discussionmentioning

confidence: 99%

Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series

Roh

Kwon

et al. 2022

Children

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As adolescents started to be vaccinated against coronavirus disease 2019 (COVID-19), suspected myocarditis and pericarditis related to the vaccine were reported in adolescents. According to the Korea Disease Control and Prevention Agency (KDCA), 2,796,270 persons aged 12–18 years were fully vaccinated by December 8. Among these, 9223 adverse events were reported (0.33%). We aimed to elucidate the clinical courses and short-term outcomes for adolescents aged 12–18 with cardiac symptoms and suspected myo- or peri-carditis related to COVID-19 vaccination in South Korea. Methods: We retrospectively collected data on patients ≤ 18 years of age who had suspected myocarditis or pericarditis within 30 days of COVID-19 vaccination, from July 2021 to January 2022. Results: We reported on 40 adolescents in different South Korean provinces at two centers. Twenty-six cases (65%) were male, and the median age was 16 years (range, 13–18; IQR 14.5–17). Twenty-five cases (62.5%) occurred at the first dose, and fifteen (37.5%) occurred after the second dose. Symptoms started at a median of 2 days (range 0–29 days; IQR 1–5 days) after vaccination. The patients were treated with nonsteroidal anti-inflammatory drugs (77.5%), intravenous immunoglobulin (2.5%), glucocorticoids (20%), colchicine (5%), or no therapy (15%). Five patients (12.5%) required intensive care unit admission; one patient needed inotropic/vasoactive support. No patients required extracorporeal membrane oxygenation or died. The median hospital stay was one day (range 0–8 days; IQR 0–2 days). Twenty-one patients (52.5%) had an abnormal electrocardiogram; among these, seven patients had an elevated ST segment, six patients (15%) had decreased ejection fraction (<55%), and LV function was completely recovered in all of them. Conclusions: Most cases of suspected myocarditis after COVID-19 vaccination in adolescents ≤ 18 years had mild symptoms and clinical courses, as well as a complete recovery. Further studies are needed to evaluate long-term outcomes.

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Section: Discussionmentioning

confidence: 99%

Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series

Roh

Kwon

et al. 2022

Children

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“…Monitoring for adverse effects has focused on reactogenicity, cardiovascular side effects and anaphylactic response to the vaccine. Common short term side effects include injection site symptoms, fever, headache, fatigue and myalgia [10,11]. Vaccination against COVID-19 in children and adolescents has been shown to be both effective and safe, even when there are underlying comorbidities [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

What Do We Know About Abnormal Uterine Bleeding Following Vaccination Against Covid-19 After Two and A Half Years Of Experience? A Systematic Review and Meta- Analysis

Sharon,

Maymon,

Svirsky

et al. 2024

Preprint

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Vaccination against COVID-19 is regarded to be most effective in preventing morbidity and mortality and limiting the spread of the virus. Publications in the media and scientific journals have raised a concern regarding abnormal uterine bleeding as a COVID-19 vaccine side effect. We aimed to estimate the prevalence of abnormal uterine bleeding after vaccination against COVID-19. Medline, PubMed, Embase and Google Scholar databases were searched between January 2020 and June 2022. English-language studies, including at least four women with abnormal uterine bleeding. Eligible studies were assessed for risk of bias using the Newcastle-Ottawa Scale. Data synthesis was accomplished by meta-analysis of frequencies of the abnormal uterine bleeding rate and meta-regression of the rate adjusted for the type of vaccine and number of vaccinations. There were 12 eligible studies including a total of 1,132,613 women of whom 41,344 (31.3%, 95CI 11.7-55.1%) reported abnormal bleeding following vaccination. Nine studies included clinical presentation: the abnormality was menorrhagia in 38%, irregular menses in 28%, intermenstrual bleeding in 12% and delayed menses in 9%). There was considerable heterogeneity in results which could not be accounted for by the method of recording abnormal bleeding, vaccine manufacturer or number of doses. COVID-19 vaccine carries the inconvenience of abnormal uterine bleeding in almost one-third of the women vaccinated, mostly irregular menses or menorrhagia. In addition, the innovative vaccine mechanism could be used against various potential targets, further highlighting the need to assess vaccine side effects.

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Unraveling the Mystery of COVID-19 Postvaccination Myocarditis: A Systematic Review of Current Cases

Cited by 2 publications

References 29 publications

Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series

Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series

What Do We Know About Abnormal Uterine Bleeding Following Vaccination Against Covid-19 After Two and A Half Years Of Experience? A Systematic Review and Meta- Analysis

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