Unraveling the Metastatic Niche in Breast Cancer Bone Metastasis through Single-Cell RNA Sequencing
Xiangyu Li,
Ziyu Gao,
Meiling Yang
et al.
Abstract:Breast cancer (BRCA) is characterized by a unique metastatic pattern, often presenting with bone metastasis (BoM), posing significant clinical challenges. This study employs single-cell RNA sequencing and TCGA data analysis to comprehensively compare primary tumors (PT), lymph node metastasis (LN), and BoM. Our investigation identifies a metastatic niche in BoM marked by an increased abundance of cancer-associated fibroblasts (CAFs) and reduced immune cell presence. A distinct subtype (State 1) of BRCA BoM cel… Show more
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