Unraveling the link between insulin resistance and Non-alcoholic fatty liver disease (or metabolic dysfunction-associated steatotic liver disease): A Narrative Review

Ziamanesh, Fateme; Mohammadi, Mehdi; Ebrahimpour, Sholeh; Tabatabaei-Malazy, Ozra; Mosallanejad, Asieh; Larijani, Bagher

doi:10.1007/s40200-023-01293-3

Cited by 6 publications

(3 citation statements)

References 96 publications

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“…Furthermore, individuals diagnosed with fatty liver disease face an increased likelihood of atherosclerosis, adverse cardiovascular events and higher mortality ( 35 ). Previous studies have shown that NAFLD is linked to increased levels of IR, a significant pathophysiological factor that plays a role in the onset and advancement of the disease ( 36 ). In addition, the elastic fibers in the inner layer of the artery undergo degeneration and the intima becomes hard, which can lead to an increase in arterial hardness ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

Associations between estimated glucose disposal rate and arterial stiffness and mortality among US adults with non-alcoholic fatty liver disease

Song,

Ma,

Yin

2024

Front. Endocrinol.

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BackgroundThe estimated glucose disposal rate (eGDR), an effective indicator of insulin resistance, has been related to acute coronary syndrome, ischemic stroke and heart failure. This study aims to explore the relationship between eGDR and arterial stiffness, all-cause mortality and cardiovascular mortality in patients with non-alcoholic fatty liver disease (NAFLD).MethodsParticipants with NAFLD were chosen from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. The main outcomes are arterial stiffness (represented by estimated pulse wave velocity, ePWV), all-cause and cardiovascular mortality. Multiple cox regression models, restricted cubic spline, sensitivity analysis and subgroup analysis were carried out to investigate the correlation between the insulin resistance indicators and mortality and arterial stiffness. Furthermore, receiver operating characteristic curves were used to compare the predictive value of the eGDR with the triglyceride-glucose (TyG) index and the homeostasis model assessment of insulin resistance (HOMA-IR) for all-cause and cardiovascular mortality.ResultsIn this study, a total of 4,861 participants were included for analysis. After adjusting confounding factors in the multivariate weighted cox regression model, the eGDR was inversely associated with the all-cause mortality (Q4 vs. Q1, HR =0.65 (0.48-0.89, P=0.01) and cardiovascular mortality (Q4 vs. Q1, HR =0.35 (0.19-0.65, P<0.001). Compared with TyG index and HOMA-IR, the eGDR shows excellent predictive value in all-cause mortality (0.588 vs. 0.550 vs. 0.513, P < 0.001) and cardiovascular mortality (0.625 vs. 0.553 vs. 0.537, P < 0.001). In addition, we found a significant negative correlation between eGDR and arterial stiffness (β=-0.13(-0.14–0.11, P< 0.001). However, TyG index and HOMA-IR showed no significant correlation to arterial stiffness.ConclusionsLow eGDR (an indicator of insulin resistance) levels are related to an increased risk of arterial stiffness and mortality in NAFLD patients in the United States.

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Section: Discussionmentioning

confidence: 99%

Associations between estimated glucose disposal rate and arterial stiffness and mortality among US adults with non-alcoholic fatty liver disease

Song,

Ma,

Yin

2024

Front. Endocrinol.

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“…Предложенный подход основывался на том факте, что NAFLD является главным образом следствием системной метаболической дисфункции, в частности наличия МС [1,3,[18][19][20][21]. Другим обстоятельством, которое необходимо учитывать при обсуждении данной нозологии, представляется многофакторность этиопатогенеза, который включает особенности питания и потребления алкоголя, нарушение целостности кишечного барьера и особенности микробиоты кишечника, дисфункцию субклеточных структур (митохондрий, эндоплазматического ретикулума), а также нарушение обмена веществ и/или гормональные расстройства [20,[22][23][24][25][26][27]. Выдвинуты предложения по изменению термина NAFLD с заменой определения «неалкогольная» на один из вариантов, указывающих на основной вклад в поражение печени одного из перечисленных факторов патогенеза [28,29].…”

Section: эволюция номенклатурыunclassified

The clinician's view on the advantages and contradictions of the new nomenclature of steatotic liver disease: A review

Pavlov,

Teplyuk,

Lazebnik

et al. 2024

Terapevticheskii arkhiv

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In September 2023, the European Association for the Study of the Liver (EASL) updated the disease nomenclature for non-alcoholic (metabolically associated) fatty liver disease. The goals of the revision were to increase awareness among health care professionals, civil society and patients about the disease, its course, treatment and outcomes; combating stigma; focusing on the initial etiological factor, including the main (cardiometabolic) risk of disease progression; improved diagnosis based on disease biomarkers; positive impact on the potency to search for new drugs; the ability to provide personalized medical care. The terms “non-alcoholic” and “fatty” were considered stigmatizing, and therefore, it was proposed to use the term steatotic liver disease (SLD) as the name of this nosology. The terms non-alcoholic fatty liver disease (NAFLD) or metabolic associated fatty liver disease (MAFLD) have been replaced by the term metabolic dysfunction-associated steatotic liver disease (MASLD). In the case of being combined with an alcohol factor, a diagnosis in which metabolic dysfunction is combined with alcoholic liver disease is referred to as MetALD. The fundamental principle in the diagnosis of MASLD is the presence of at least one of the cardiometabolic risk factors. Alcohol consumption interacts with cardiometabolic risk factors and increases the risk of SLD decompensation. The term nonalcoholic steatohepatitis (NASH), according to the new nomenclature, has been replaced by the term metabolic dysfunction-associated steatohepatitis (MASH). The adoption of the new nomenclature should help to increase awareness about the disease, its course and outcomes, as well as improve the quality of diagnosis and treatment.

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“…NC, as an indicator of upper body adiposity, is associated with systolic and diastolic blood pressure, total cholesterol, low-density lipoprotein (LDL), triglycerides, fasting blood glucose, uric acid levels, insulin resistance, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD), and, as a result, cardiovascular diseases [ 16 , 18 – 20 ]. There is some controversy over the indication of using NC and its predictive role for body composition [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Anthropometric Indices as Screening Tools for Obesity: A Study on Healthy Iranians

Alirezaei,

Soori,

Irilouzadian

et al. 2023

Journal of Nutrition and Metabolism

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Background and Aims. Upper body fat distribution is more related to cardiometabolic diseases than central obesity. Neck circumference (NC) and neck-to-height ratio (NHtR) are two indicators of upper body obesity that are affordable, easy to obtain, highly reproducible, and more practical in the crowded health centers than the classic anthropometric indices. Methods. 18–65-year-old individuals with no past medical history were included. After obtaining written informed consent, they were screened for hypertension, high blood glucose, and other abnormal laboratory results. Data were analyzed using SPSS and Mann–Whitney U test, Chi square test, Spearman’s correlation coefficient, and ROC curve. Results. In our 2,812 participants, NC had the lowest area under the curve (AUC) in both male and female obese and overweight subjects. NHtR and hip circumference (HC) had the highest AUC in men and women with obesity, respectively. The highest sensitivity for overweight men and women belonged to waist circumference (WC) and waist-to-height ratio (WHtR), respectively, and for both males and females with obesity, NHtR had the highest sensitivity. The cutoff point of NHtR had the same value for males and females. HC and NHtR had the highest positive likelihood ratio (PLR) for obesity in men. In addition, HC and WC had the highest PLR for obesity in women. Conclusion. In this study, we revealed that NC had the lowest and NHtR and HC had the highest predictive value for obesity. Furthermore, for both males and females with obesity, NHtR had the highest sensitivity. HC had the highest PLR for obesity in both genders. Our results warrant prospective studies to evaluate the role of NHtR and other novel anthropometric indices in the risk of cardiometabolic diseases.

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Unraveling the link between insulin resistance and Non-alcoholic fatty liver disease (or metabolic dysfunction-associated steatotic liver disease): A Narrative Review

Cited by 6 publications

References 96 publications

Associations between estimated glucose disposal rate and arterial stiffness and mortality among US adults with non-alcoholic fatty liver disease

Associations between estimated glucose disposal rate and arterial stiffness and mortality among US adults with non-alcoholic fatty liver disease

The clinician's view on the advantages and contradictions of the new nomenclature of steatotic liver disease: A review

Novel Anthropometric Indices as Screening Tools for Obesity: A Study on Healthy Iranians

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