Unraveling the intricacies of cancer‐associated fibroblasts: a comprehensive review on metabolic reprogramming and tumor microenvironment crosstalk
Sana Ahuja,
Niti Sureka,
Sufian Zaheer
Abstract:Cancer‐associated fibroblasts (CAFs) are crucial component of tumor microenvironment (TME) which undergo significant phenotypic changes and metabolic reprogramming, profoundly impacting tumor growth. This review delves into CAF plasticity, diverse origins, and the molecular mechanisms driving their continuous activation. Emphasis is placed on the intricate bidirectional crosstalk between CAFs and tumor cells, promoting cancer cell survival, proliferation, invasion, and immune evasion. Metabolic reprogramming, … Show more
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