Unraveling the impact of hyperleptinemia on female reproduction: Insights from transgenic pig model
Muhammad Jamal,
Yixiao Cheng,
Deling Jiao
et al.
Abstract:Background Infertility is a growing global health concern affecting millions of couples worldwide. Among several factors, an extreme body weight adversely affects reproductive functions. Leptin is a well-known adipokine that serves as an endocrine signal between adiposity and fertility. However, the exact mechanisms underlying the effects of high leptin on female reproduction remain unclear. Methods Transgenic pig overexpressing leptin (♀) were produced by back cross and screened for leptin overexpression, and… Show more
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