Unraveling the Immunopathological Landscape of Celiac Disease: A Comprehensive Review
Yonatan Shneor Patt,
Adi Lahat,
Paula David
et al.
Abstract:Celiac disease (CD) presents a complex interplay of both innate and adaptive immune responses that drive a variety of pathological manifestations. Recent studies highlight the role of immune-mediated pathogenesis, pinpointing the involvement of antibodies against tissue transglutaminases (TG2, TG3, TG6), specific HLA molecules (DQ2/8), and the regulatory role of interleukin-15, among other cellular and molecular pathways. These aspects illuminate the systemic nature of CD, reflecting its wide-reaching impact t… Show more
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