Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber
Jose Xavier Neto,
Luana Nunes Santos,
Angela Maria Sousa Costa
et al.
Abstract:Optimal cardiac function requires appropriate contractile proteins in each heart chamber. Atria require slow myosins to act as variable reservoirs, while ventricles demand fast myosin for swift pumping functions. To achieve this functional distribution, myosins are thus under chamber-biased cis-regulatory control, with a failure in proper regulation of myosin genes leading to severe congenital heart dysfunction. However, the precise regulatory input leading to cardiac chamber-biased expression remains uncharte… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.