Unraveling the effect of surfactant chain length on the binding interaction of curcumin with cationic and non‐ionic micelles

Abstract

Major drawbacks of using curcumin as a potential multifunctional drug are its very low water solubility and lack of bio-availability. For this purpose we have used surfactants to increase the solubility of curcumin in aqueous medium and to assess its hydrophilic and hydrophobic interactions with micelles. In order to understand the molecular mechanism of the interaction of curcumin with surfactants, we have employed cationic and non-ionic surfactants. We have used hexadecyl(cetyl) trimethylammonium bromide (CTAB), tetradecyltrimethylammonium (TTAB) and dodecyltrimethylammonium bromide (DTAB) as cationic surfactants of varying hydrocarbon tail dimension and octylphenol ethoxylate with 10 moles of ethyelene oxide (OPE-10), octylphenol ethoxylate with 16 moles of ethyelene oxide (OPE-16), octylphenol ethoxylate with 30 moles of ethyelene oxide (OPE-30) as nonionic surfactants of varying poly(ethylene oxide) hydrophilic head dimension. From the increase in fluorescence intensity of curcumin in the presence of surfactants, we had estimated the apparent binding constant (K b ) of curcumin-micelle complex formation. The evaluated K b values between curcumin and CTAB, TTAB, and DTAB were 7.75 Â 10 5 , 3.44 Â 10 5 , and 0.78 Â 10 5 L mol À1 , respectively. In the case of non-ionic surfactants, the estimated K b values of curcumin with OPE-10, OPE-16, and OPE-30 were 4.90 Â 10 6 , 3.82 Â 10 6 , and 0.58 Â 10 6 L mol À1 , respectively. Thus, it was found that K b values were somehow greater in the case of non-ionic surfactants than cationic surfactants. From the fluorescence quenching study it was revealed that the probable location of curcumin was the Stern layer and the palisade layer in the case of cationic and non-ionic micelles, respectively. Our results might be useful to overcome challenges associated with the delivery of curcumin as a multifunctional drug molecule.

Modeling the Encapsulation of Turmeric in Nanoemulsions

“…2 shows oriented and agglomerated structures. The results are in agreement with literature data (Das et al, 2022;Hughes et al, 2021;Nuraje et al, 2013;Varasteanu, 2014) related to the formation of structures in multiple water-oil-water emulsions. The best dispersion for turmeric was in sample 3 with polymethylene-α, ω-bis (N, N-dialkyl-N-deoxy-d-glucitolammonium iodides-Gemini 2.…”

“…Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione called as diferuloylmethane) is a bioactive constituent of turmeric, the Indian spice, obtained from the "Curcuma longa" rhizome and has been known for centuries as a household remedy to many ailments. Modern scientific research works (Das et al, 2022;Hughes et al, 2021;Nuraje et al, 2013;Varasteanu, 2014;Bungay and Smolders, 1986) are just beginning to study the positive impact of turmeric for leather. Clinical development of turmeric is mainly hindered due to its low aqueous solubility (20 µg/mL) which can be improved by increasing the pH of the solution.…”

Proceedings of the 9th International Conference on Advanced Materials and Systems

“…2 shows oriented and agglomerated structures. The results are in agreement with literature data (Das et al, 2022; related to the formation of structures in multiple water-oil-water emulsions. The best dispersion for turmeric was in sample 3 with polymethylene-α, ω-bis (N, N-dialkyl-N-deoxy-d-glucitolammonium iodides-Gemini 2.…”

“…Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione called as diferuloylmethane) is a bioactive constituent of turmeric, the Indian spice, obtained from the "Curcuma longa" rhizome and has been known for centuries as a household remedy to many ailments. Modern scientific research works (Das et al, 2022;Bungay and Smolders, 1986) are just beginning to study the positive impact of turmeric for leather. Clinical development of turmeric is mainly hindered due to its low aqueous solubility (20 µg/mL) which can be improved by increasing the pH of the solution.…”

Facile and cost-effective fabrication of wearable alpha-naphtholphthalein-based halochromic sensor for wound pH monitoring

“…In the Naph-CTAB solution, CTAB dissociates into CTA+ and Br-counterions in water [35,36]. The electrostatic interactions of the CTA+ counter ion can form a closed network by reducing the repulsive force and stabilizing the transition state during micellization [37,38]. In other words, during micellization, charged CTAB molecules interact with the Naph dye through the micelle effect without a large electrostatic barrier, creating Naph-CTAB micelles.…”