Unraveling the complex pathophysiology of white matter hemorrhage in intracerebral stroke: A single‐cell RNA sequencing approach
Lisha Ye,
Xiaoyan Tang,
Jun Zhong
et al.
Abstract:AimThis study aims to elucidate the cellular dynamics and pathophysiology of white matter hemorrhage (WMH) in intracerebral hemorrhage (ICH).MethodsUsing varying doses of collagenase IV, a consistent rat ICH model characterized by pronounced WMH was established. Verification was achieved through behavioral assays, hematoma volume, and histological evaluations. Single‐cell suspensions from the hemorrhaged region of the ipsilateral striatum on day three post‐ICH were profiled using single‐cell RNA sequencing (sc… Show more
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