Unraveling Structural Disparities in Human and Mycobacterium Tuberculosis Type-I Fatty Acid Synthase
Akhil Kumar,
Priyanka Rama,
Harshwardhan H. Katkar
Abstract:Type-I Fatty acid synthase is an essential enzyme present in diverse species including humans (hFAS-I) and mycobacterium tuberculosis (MtbFAS-I), and is an attractive antibacterial drug target. A structural comparison of the two enzymes is essential in order to identify selective drug targets in MtbFAS-I. In this work, we have analyze equilibrium average structures of hFAS-I and MtbFAS-I obtained from 100 ns long molecular dynamics simulation trajectories. Our structural analysis revealed that two of the seven… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.