Unraveling Stress‐Induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism

Zhang, Wendi; Wang, Chi; Li, Zhongjun; Lu, Zhenzhen; Li, Yiye; Yin, Jun; Zhou, Yu; Gao, Xingfa; Fang, Ying; Nie, Guangjun; Zhao, Yuliang

doi:10.1002/adma.201202678

Cited by 215 publications

(152 citation statements)

References 46 publications

Supporting

Mentioning

146

Contrasting

Order By: Relevance

“…However, in most papers, there have been only few specialized techniques for characterization of GFMs used for ecotoxicity investigations. These include SEM (Anjum et al 2013;2014;Begum et al 2011;LiQiang et al 2012;Zanni et al 2012), TEM (Anjum et al 2013;2014;Begum et al 2011, Begum and Fugetsu 2013, Gollavelli and Ling 2012Wang et al 2011a, b), AFM (Ahmed and Rodrigues 2013;Gollavelli and Ling 2012;Begum et al 2011;Zhang et al 2012b;Zhou et al 2012); XPS (Ahmed and Rodrigues 2013;Gollavelli and Ling 2012;Wang et al 2011a, b;Zhang et al 2012b), FT-IR (Zanni et al 2012;Zhou et al 2012), and Raman spectroscopy (Anjum et al 2013;2014;Ahmed and Rodrigues 2013;Wang et al 2011a, b;Zhang et al 2012b). In some single articles, there can be also found investigations of zeta potential (Begum and Fugetsu 2013;Zhou et al 2012), dynamic light scattering particle size analysis (Begum and Fugetsu 2013;Pretti et al 2014;Zhang et al 2012b), cyclic voltammetry analysis (Wang et al 2011a, b) as well as extinction spectroscopy (LiQiang et al 2012).…”

Section: Characterization Of Gfms Used For Ecotoxicity Investigationsmentioning

confidence: 96%

See 1 more Smart Citation

The ecotoxicity of graphene family materials: current status, knowledge gaps and future needs

Jastrzębska

Olszyna

2015

J Nanopart Res

View full text Add to dashboard Cite

Recently, graphene family materials (GFMs) have been introduced among all fields of science and still get numerous attention. Also, the applicability of these materials in many areas makes them very attractive. GFMs have attracted both academic and industrial interest as they can produce a dramatic improvement in materials properties at very low filler content. The aim of this review is to identify, summarize, and present the first available information on the influence of GFMs on soil and water environment as well as identify the knowledge gaps and indicate the directions for the next generation of the original scientific investigations. The paper also presents our first preliminary impact assessment and potential pathways of GFMs distribution in the environment. We used as an example the reduced graphene oxide/Al 2 O 3 nanocomposite (RGO/Al 2 O 3 ) that has been previously designed and synthesized by us. Authors believe that further work should focus on improvement of characterization methodology applicable for ecotoxicity analyses and possible interactions between GFMs and different living ecosystems. Consequently, the potential impact of graphene and its derivatives on environmental health is a matter of academic interest. However, potential hazards sufficient for risk assessment and concerned with GFMs usage in consumer products first need to be investigated and identified. Further research should focus on gathering knowledge on GFMs properties for life cycle analyses, which still poses a great challenge for scientists.

show abstract

Section: Characterization Of Gfms Used For Ecotoxicity Investigationsmentioning

confidence: 96%

“…Graphene oxide (GO) and GO/PLL-PEG Dynamic light scattering (DLS) The average sizes of the GO and GO/PP nanosheets were 80 and 106 nm, respectively (Zhang et al 2012b) Atomic force microscopy (AFM)…”

Section: Scanning Electronic Microscopy (Sem)mentioning

confidence: 99%

The ecotoxicity of graphene family materials: current status, knowledge gaps and future needs

Jastrzębska

Olszyna

2015

J Nanopart Res

View full text Add to dashboard Cite

show abstract

“…For example, because of the high electron density on the surface, 45 graphene oxide nanoparticles act as electron transfer mediators and catalyze H 2 O 2 decomposition to OH in Caenorhabditis elegans (C. elegans). 46 Involvement in physiological redox reactions has emerged as an important mechanism accounting for the toxicity of nanoparticles. 46,47 For this reason, special attention should be paid to the health risks of nanoparticles under some pathophysiological conditions like diabetes and aging.…”

Section: Absorption Distribution Metabolism and Excretion Of Nanopmentioning

confidence: 99%

“…46 Involvement in physiological redox reactions has emerged as an important mechanism accounting for the toxicity of nanoparticles. 46,47 For this reason, special attention should be paid to the health risks of nanoparticles under some pathophysiological conditions like diabetes and aging. A noteworthy question regards the effects of both in vitro and in vivo metabolism of nanoparticles on their toxicity.…”

Section: Absorption Distribution Metabolism and Excretion Of Nanopmentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

View full text Add to dashboard Cite

Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

show abstract

“…37,38 The great majority, though, agrees that GO causes oxidative stress inducing the formation of reactive oxygen species. [39][40][41] In our case, the observed effects are mostly related to the GO composition in terms of functional groups and their interaction with the surrounding media, as it will be discussed below.…”

Section: Effect Of Go On Pollen Performances and Viabilitymentioning

confidence: 99%

Graphene oxide impairs the pollen performance of Nicotiana tabacum and Corylus avellana suggesting potential negative effects on the sexual reproduction of seed plants

Carniel

Gorelli

Flahaut

et al. 2018

Environ. Sci.: Nano

View full text Add to dashboard Cite

The production of graphene based materials (GBMs) is steadily increasing but the effects of the possible release of GBMs in the environment are far from being understood. Graphene oxide (GO) is among the most active GBMs and it causes widely varying effects on the vegetative body of seed plants. However, nothing is known yet about its potential effects on the reproductive process. This study addresses the effects of GO on pollen germination and pollen tube elongation in the model species Nicotiana tabacum and in the non-model species Corylus avellana. In vitro germination experiments were conducted without or with GO (control and treated samples, respectively) at concentrations of 25, 50 and 100 μg mL . Pollen germination and tube elongation were affected at GO concentrations ≥50 μg mL ) samples demonstrated that the main factor influencing the pollen performance is the acidic properties of GO. This might affect the reproductive process of numerous seed plants thus being relevant from an environmental point of view.

show abstract

Unraveling Stress‐Induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism

Cited by 215 publications

References 46 publications

The ecotoxicity of graphene family materials: current status, knowledge gaps and future needs

The ecotoxicity of graphene family materials: current status, knowledge gaps and future needs

Perturbation of physiological systems by nanoparticles

Graphene oxide impairs the pollen performance of Nicotiana tabacum and Corylus avellana suggesting potential negative effects on the sexual reproduction of seed plants

Contact Info

Product

Resources

About