Unraveling resistance mechanisms in combination therapy: A comprehensive review of recent advances and future directions

Morales-Durán, Nami; León-Buitimea, Angel; Morones-Ramírez, José R.

doi:10.1016/j.heliyon.2024.e27984

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Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e27984

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Unraveling resistance mechanisms in combination therapy: A comprehensive review of recent advances and future directions

Nami Morales-Durán,

Angel León-Buitimea,

José R. Morones-Ramírez

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2024

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Cited by 3 publications

References 99 publications

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Harnessing biotechnology for penicillin production: Opportunities and environmental considerations

Haque,

Nath,

Johnston

et al. 2024

Science of The Total Environment

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Harnessing biotechnology for penicillin production: Opportunities and environmental considerations

Haque,

Nath,

Johnston

et al. 2024

Science of The Total Environment

View full text Add to dashboard Cite

Climate warming promotes collateral antibiotic resistance development in cyanobacteria

Wang,

Chen,

Zhang

et al. 2024

Water Research

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High Prevalence of Colistin-Resistant Encoding Genes Carriage among Patients and Healthy Residents in Vietnam

Le,

Khong,

Phan

et al. 2024

Medicina

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Background and Objectives: We aimed to investigate the carriage of colistin-resistant genes among both patients with a history of antibiotic exposure and apparently healthy adults with no recent healthcare contact. Materials and Methods: Stool swabs were collected from healthy people, and specimens were collected at the infection foci from the patients. Eleven primer/probe sets were used to perform the Multiplex Real-Time PCR assay with the QuantiNova Multiplex Probe PCR kit for screening the carriage of colistin-resistant genes (mcr-1 to mcr-10) and 16S rRNA gene as internal control. Results: In total, 86 patients and 96 healthy residents were included. Twenty two patients (25.9%) were positive with at least one colistin-resistance encoding gene. The mcr-1 gene was the most frequent (16.5%), followed by mcr-9, mcr-6, and mcr-4 genes, where the prevalence was 11.8%, 10.6%, and 9.4%, respectively. No patient was positive with mcr-3, mcr-7, and mcr-8 genes. Eight patients (9.4%) were positive with multiple colistin-encoding genes. Twenty-three healthy people (24.0%) were positive with at least one colistin-resistance encoding gene, and the mcr-10 gene was the most frequent (27.0%), followed by the mcr-1, mcr-8, and mcr-9 genes, where the prevalence was 24.3%, 21.6%, and 13.5%, respectively. No person was positive with the mcr-2 and mcr-5 genes. Conclusions: Our findings underscore the urgent need for enhanced surveillance, infection control measures, and stewardship interventions to mitigate the spread of colistin resistance in Vietnam.

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Unraveling resistance mechanisms in combination therapy: A comprehensive review of recent advances and future directions

Cited by 3 publications

References 99 publications

Harnessing biotechnology for penicillin production: Opportunities and environmental considerations

Harnessing biotechnology for penicillin production: Opportunities and environmental considerations

Climate warming promotes collateral antibiotic resistance development in cyanobacteria

High Prevalence of Colistin-Resistant Encoding Genes Carriage among Patients and Healthy Residents in Vietnam

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