Unraveling hepatic consequences of intrauterine growth restriction and catch- up growth: Insights from histological, biochemical, and metabolomic analysis in rats Running title: Hepatic Metabolomics and Intrauterine Growth Retardation
Mukaddes Eşrefoğlu,
Sahabettin Selek,
Fatmanur Koktasoglu
et al.
Abstract:Intrauterine growth restriction (IUGR) is increasingly recognized as a significant risk factor for metabolic disorders in adulthood. Employing a multi-faceted approach encompassing histopathological, immunohistochemical, biochemical, Western-blotting, and metabolomics analyses, the study aimed to elucidate potential metabolite markers of IUGR, and catch-up growth-related metabolic disturbances and the underlying metabolic pathways implicated in IUGR pathogenesis. This study cohort comprised 54 male siblings fr… Show more
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