Unraveling Glioblastoma Heterogeneity: Introducing SP2G Method for Identifying Invasive Sub-Populations
Michele Crestani,
Nikolaos Kakogiannos,
Fabio Iannelli
et al.
Abstract:Glioblastomas exhibit remarkable heterogeneity at various levels, including motility modes and mechanoproperties that contribute to tumor resistance and recurrence. In a recent study using gridded micropatterns mimicking the brain vasculature, we linked glioblastoma cell motility modes, mechanical properties, formin content, and substrate chemistry. We now introduce SP2G (SPheroid SPreading on Grids), an analytic platform designed to identify the migratory modes of patient-derived glioblastoma cells and rapidl… Show more
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