Unraveling Exogenous DNA Processing in Cas4‐Lacking Crispr Systems: A Novel Bypass Pathway Explored
Xinming Su,
Xiaoyu Jin,
Zehua Wang
et al.
Abstract:Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated (Cas) systems are widely distributed adaptive immune systems found in prokaryotes. The process involves three main stages: adaptation, expression, and interference. While the adaptation stage has been extensively studied, there is still an incomplete understanding of the mechanisms underlying the capture, trimming, and integration of exogenous DNA. For instance, Cas4, a CRISPR‐Cas protein with endonuclease activity, is respons… Show more
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