Unraveling clinical outcomes of long-term cART treatment in HIV-1 patients with or without the Brazilian GWGR motif in the V3 loop
Victor Ângelo Folgosi,
Shirley Vasconcelos Komninakis,
Luciano Lopes
et al.
Abstract:The presence of genetic mutations in HIV poses a significant challenge,
potentially leading to antiretroviral resistance and hampering therapeutic
development. The Brazilian population has presented variations in the HIV
envelope V3 loop gene, especially the GWGR motif. This motif has been linked to
reduced transmission potential and slower CD4+ T cell decline. This study aimed
to assess clinical outcomes in patients with HIV-1 infected with strains
containing the GWGR motif compared with those without it duri… Show more
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