Unproven diagnostic and therapeutic techniques

James, John M.

doi:10.1007/s11882-002-0045-7

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…An alternative proteomic method uses one of several improved antibody-microarray technologies such as the Zymox protein biochips or antibody ELISA arrays [49][50][51][52]. The technology works on the concept of capturing the protein of interest using antibody-based platform.…”

Section: Antibody Panel/array Approachmentioning

confidence: 99%

Neuroproteomics and systems biology‐based discovery of protein biomarkers for traumatic brain injury and clinical validation

Kobeissy

Sadasivan

Oli

et al. 2008

Proteomics Clinical Apps

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The rapidly growing field of neuroproteomics has expanded to track global proteomic changes underlying various neurological conditions such as traumatic brain injury (TBI), stroke, and Alzheimer's disease. TBI remains a major health problem with approximately 2 million incidents occurring annually in the United States, yet no affective treatment is available despite several clinical trials. The absence of brain injury diagnostic biomarkers was identified as a significant road-block to therapeutic development for brain injury. Recently, the field of neuroproteomics has undertaken major advances in the area of neurotrauma research, where several candidate markers have been identified and are being evaluated for their efficacy as biological biomarkers in the field of TBI. One scope of this review is to evaluate the current status of TBI biomarker discovery using neuroproteomics techniques, and at what stage we are at in their clinical validation. In addition, we will discuss the need for strengthening the role of systems biology and its application to the field of neuroproteomics due to its integral role in establishing a comprehensive understanding of specific brain disorder and brain function in general. Finally, to achieve true clinical input of these neuroproteomic findings, these putative biomarkers should be validated using preclinical and clinical samples and linked to clinical diagnostic assays including ELISA or other high-throughput assays.

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Section: Antibody Panel/array Approachmentioning

confidence: 99%

Neuroproteomics and systems biology‐based discovery of protein biomarkers for traumatic brain injury and clinical validation

Kobeissy

Sadasivan

Oli

et al. 2008

Proteomics Clinical Apps

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“…There are no standardized tests to evaluate non-IgEmediated food reactions at this time (6)(7)(8)(9)(10). Investigational approaches include measuring serum food-specific IgG (SIgG) and SIgG subclass 4 (SIgG 4 ) antibodies and performing atopy patch tests (APTs) (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28).…”

mentioning

confidence: 99%

Useful Biomarkers in Pediatric Eosinophilic Duodenitis and Their Existence: A Case‐control, Single‐blind, Observational Pilot Study

Neilan

Dowling

Taylor

et al. 2010

J. pediatr. gastroenterol. nutr.

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Allergy screening for the foods tested was not useful as a biomarker for eosinophilic duodenitis in this small study. A higher rate of positive reactions to patch testing was observed in the control group than previous studies have reported. The incidence of a positive food patch test in nonselected subjects needs further investigation. Method standardization and establishment of reference intervals are needed for atopy patch tests, SIgG, and SIgG4 to better evaluate the clinical value of these measures.

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Common respiratory manifestations of food allergy: A critical focus on otitis media

James¹

2004

Curr Allergy Asthma Rep

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Previous investigations have established the pathogenic role of food allergy in respiratory tract symptoms, which rarely occur in isolation. Specific foods have been implicated in these reactions. The role of food allergy in otitis media is controversial, probably uncommon, and further studies are needed. Food-induced asthma is more common in young pediatric patients, especially those with atopic dermatitis. Asthma induced by food allergy is considered a risk factor for fatal and near-fatal anaphylactic reactions. Moreover, food allergy can elicit airway hyperreactivity and asthmatic responses. Therefore, evaluation for food allergy should be considered among patients with recalcitrant or otherwise unexplained acute severe asthma exacerbations; asthma triggered by ingestion of particular foods; and asthma and other manifestations of food allergy (eg, anaphylaxis, moderate to severe atopic dermatitis).

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Unproven diagnostic and therapeutic techniques

Cited by 5 publications

References 16 publications

Neuroproteomics and systems biology‐based discovery of protein biomarkers for traumatic brain injury and clinical validation

Neuroproteomics and systems biology‐based discovery of protein biomarkers for traumatic brain injury and clinical validation

Useful Biomarkers in Pediatric Eosinophilic Duodenitis and Their Existence: A Case‐control, Single‐blind, Observational Pilot Study

Common respiratory manifestations of food allergy: A critical focus on otitis media

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