Unpredicted formation of copper(ii) complexes containing 2-thiophen-2-yl-1-thiophen-2-ylmethyl-1H-benzoimidazole and their most promising in vitro cytotoxicity in MCF-7 and HeLa cell lines over cisplatin

Abstract

An in situ reaction of CuCl2·2H2O, o-phenylenediamine, thiophene-2-carbaldehyde and sodium azide in methanol afforded complex 1a.

Dinuclear copper(II) complex with a benzimidazole derivative: Crystal structure, theoretical calculations, and cytotoxic activity

“…As observed in Figure , the UV–Vis absorption spectrum of the complex underwent a red shift in relation to the free dppb as a consequence of the ligand coordination. A similar behavior was observed for other copper(II) complexes bearing benzimidazole as ligand . Moreover, the electronic spectrum of the complex, measured in dmso solution at 5 m m (inset in Figure ), reveals a single broad band centered at 748 nm due to d–d transition with ε = 80 M −1 cm −1 .…”

“…Moreover, under the same experimental conditions, the commercially available drugs cisplatin (IC 50 = 1.1 ± 0.2 μ m ) and carboplatin (IC 50 = 10 ± 1 μ m ) exhibit cytotoxic activity in the same order of magnitude as the newly synthesized compound . Similarly, previous studies of copper‐based complexes containing benzimidazole derivatives have demonstrated that the antineoplastic potential of benzimidazoles enhance upon copper(II) coordination …”

“…Metal complexes bearing benzimidazole derivatives with considerable structural diversity, including mononuclear and multinuclear compounds, have been recently reported by many groups while some ring‐like coordination compounds have also been reported . This assortment of metal–organic structures is favored by the versatile coordination modes of benzimidazole‐type ligands.…”

“…Regarding the antiproliferative properties of the benzimidazole moiety as well as the ability of some of its copper(II)‐based compounds to bind to and cleave DNA, mononuclear and dinuclear complexes based on this metal were previously prepared to obtain more active anticancer agents . In all related cases, the copper(II) complexes led to a considerable enhancement of cytotoxicity against tumor cells when compared with the correspondent free benzimidazole ligands, indicating that the strategy of combining copper(II) ion with benzimidazole groups results in synergistic antiproliferative effects.…”

A pseudo trinuclear nickel–sodium complex containing tris(8‐methyl‐2‐oxo‐quinolidineamino ethylamine): Synthesis, spectral characterization, X‐ray crystallography and in vitro biological evaluations

“…The Stern–Volmer equation (I 0 /I = Ksv[Q] + 1) was used to analyse the quenching constant. This indicated that the ligand and complex could replace EB in the DNA–EB system . The K SV values were obtained as a slope from the plot of I 0 / I vs. [ Q ] evaluated for the ligand and complex as shown in Figure and Table , where I 0 is the emission intensity in the absence of the compound, I corr is the corrected emission intensity in the presence of the compound, K SV is the quenching constant and [ Q ] is the concentration of the compound.…”