Unpredictable mealtimes rather than social jetlag affects acquisition and retention of hippocampal dependent memory

Deibel, Scott H.; Lewis, Leanna M.; Cleary, Jillian; Cassell, Taylor T.S.; Skinner, Darlene M.; Thorpe, Christina M.

doi:10.1016/j.beproc.2022.104704

Cited by 2 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also suggests that some tasks might be better for detecting the type of subtle learning and memory impairments elicited by CA2 manipulations. A single massed training session to a new location and a probe trial 24 hours later (Bolding and Rudy, 2006;Deibel et al, 2014Deibel et al, , 2022, would most likely reveal impairments in both learning and retention. Along these lines CA2-silenced mice would likely also be impaired at finding a new spatial location every training day (Whishaw, 1985).…”

Section: Further Experiments Can Elucidate the Contribution Of Ca2 In...mentioning

confidence: 99%

Silencing hippocampal CA2 reduces behavioral flexibility in spatial learning

Lehr

Hitti

Deibel

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

The hippocampus is a key structure involved in learning and remembering spatial information. However the extent to which hippocampal region CA2 is involved in these processes remains unclear. Here we show that chronically silencing dorsal CA2 impairs reversal learning in the Morris water maze. After platform relocation, CA2-silenced mice spent more time in the vicinity of the old platform location and less time in the new target quadrant. Accordingly, behavioral strategy analysis revealed increased perseverance in navigating to the old location during the first day and an increased use of non-spatial strategies during the second day of reversal learning. Confirming previous indirect indications, these results demonstrate that CA2 is recruited when mice must flexibly adapt their behavior as task contingencies change. We discuss how these findings can be explained by recent theories of CA2 function and outline testable predictions to understand the underlying neural mechanisms. Demonstrating a direct involvement of CA2 in spatial learning, this work lends further support to the notion that CA2 plays a fundamental role in hippocampal information processing.

show abstract

Section: Further Experiments Can Elucidate the Contribution Of Ca2 In...mentioning

confidence: 99%

Silencing hippocampal CA2 reduces behavioral flexibility in spatial learning

Lehr

Hitti

Deibel

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…It also suggests that some tasks might be better for detecting the type of subtle learning and memory impairments elicited by CA2 manipulations. A single massed training session to a new location and a probe trial 24 h later (Bolding & Rudy, 2006; Deibel et al, 2014, 2022), would most likely reveal impairments in both learning and retention. Along these lines CA2‐silenced mice would likely also be impaired at finding a new spatial location every training day (Whishaw, 1985).…”

Section: Discussionmentioning

confidence: 99%

“…Here, mice were housed in groups, habituated to handling and transport between the colony room and behavioral room for 3 days and then were exposed to 2 days of cued learning, which may have an influence on initial learning of the hidden platform on Days 3-7. It could be that differences in CA2-silenced mice may be detect- (Bolding & Rudy, 2006;Deibel et al, 2014Deibel et al, , 2022, would most likely reveal impairments in both learning and retention.…”

mentioning

confidence: 99%

Silencing hippocampal CA2 reduces behavioral flexibility in spatial learning

et al. 2023

Self Cite

View full text Add to dashboard Cite

The hippocampus is a key structure involved in learning and remembering spatial information. However, the extent to which hippocampal region CA2 is involved in these processes remains unclear. Here, we show that chronically silencing dorsal CA2 impairs reversal learning in the Morris water maze. After platform relocation, CA2‐silenced mice spent more time in the vicinity of the old platform location and less time in the new target quadrant. Accordingly, behavioral strategy analysis revealed increased perseverance in navigating to the old location during the first day and an increased use of non‐spatial strategies during the second day of reversal learning. Confirming previous indirect indications, these results demonstrate that CA2 is recruited when mice must flexibly adapt their behavior as task contingencies change. We discuss how these findings can be explained by recent theories of CA2 function and outline testable predictions to understand the underlying neural mechanisms. Demonstrating a direct involvement of CA2 in spatial learning, this work lends further support to the notion that CA2 plays a fundamental role in hippocampal information processing.

show abstract

Unpredictable mealtimes rather than social jetlag affects acquisition and retention of hippocampal dependent memory

Cited by 2 publications

References 39 publications

Silencing hippocampal CA2 reduces behavioral flexibility in spatial learning

Silencing hippocampal CA2 reduces behavioral flexibility in spatial learning

Silencing hippocampal CA2 reduces behavioral flexibility in spatial learning

Contact Info

Product

Resources

About