Unpredictable chronic stress in juvenile or adult rats has opposite effects, respectively, promoting and impairing resilience

Ricon, Tsameret; Tóth, É.; Leshem, Micah; Braun, Katharina; Richter‐Levin, Gal

doi:10.3109/10253890.2011.572207

Cited by 50 publications

(36 citation statements)

References 33 publications

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“…Offspring enrichment amelioration of the effects of PS has not been previously reported, but its reversal of prenatal (gestational) and early postnatal adversity are documented and some reversal mechanisms elucidated (Francis et al, 2002;Sztainberg, Kuperman, Tsoory, Lebow, & Chen, 2010;Wakshlak & Weinstock, 1990;Weaver et al, 2005;Weaver, Meaney, & Szyf, 2006). The test-and sexdependent antagonism of stressors has also been noted for gestational and postnatal stressors (Lehmann, Stöhr, & Feldon, 2000;Welberg et al, 2006), and juvenile and adult stressors (Ricon, Toth, Leshem, Braun, & Richter-Levin, 2011).…”

Section: Summary Of Transgenerational Effectsmentioning

confidence: 83%

Transgenerational effects of infantile adversity and enrichment in male and female rats

Leshem

Schulkin

2011

Developmental Psychobiology

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To discover whether the accumulation of life's experiences, adverse and enriching, inform, and serve the following generation by inheritance we examine whether stress to a weanling female will influence her future offspring, whether prereproductive enrichment to the dam, or postweaning enrichment to the offspring, can reverse the transgenerational effects of stress, and whether, like adversity, enrichment might have transgenerational effects. Female rats were exposed to stressors when they were 27-29 days old. Half of these females and their controls were then raised in an enriched environment from weaning until mating at 60 days to examine whether preproduction enrichment reverses the effects of preproduction stress on offspring. Half of the offspring of each group were raised in an enriched environment after weaning, to see whether it reverses the effects of preproduction stress and buttresses prereproductive enrichment. Behavior was examined in 625 adult offspring in 16 groups covering all permutations of the experimental variables (preproduction weanling stress (PS), preproduction enrichment (PE), offspring enrichment (OE), sex). Exploration, avoidance learning, startle, and social interaction were tested. Results reveal that very early prereproductive experience in females, adverse or enriching, will transgenerationally influence their future offspring, depending on the behavior tested and sex. Our finding that enrichment, whether to the parent or offspring generation, can ameliorate the transgenerational impact of adversity, has novel implications for the malleability of transgenerational inheritance, and its individual, social, and therapeutic impact.

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Section: Summary Of Transgenerational Effectsmentioning

confidence: 83%

Transgenerational effects of infantile adversity and enrichment in male and female rats

Leshem

Schulkin

2011

Developmental Psychobiology

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“…Indeed, Das et al (2005) showed that rats subjected to chronic predictable stress exhibit increased memory performance in an aversive test (passive avoidance), while rats subjected to chronic unpredictable stress showed no significant learning. Ricon et al (2012) demonstrated that exposure to unpredictable chronic stress in adult rats produces deficits in learning and memory in the two-way shuttle avoidance task. These authors emphasize that the…”

Section: Discussionmentioning

confidence: 99%

“…Stress Downloaded from informahealthcare.com by Carleton University on 06/24/14 9 unpredictability rather than the severity of the stress protocol induces impaired cognitive function in adulthood (Ricon et al, 2012).…”

Section: J U S T a C C E P T E Dmentioning

confidence: 99%

Effect of maternal separation and chronic stress on hippocampal-dependent memory in young adult rats: evidence for the match-mismatch hypothesis

Zalosnik

Pollano

Trujillo

et al. 2014

Stress

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Adverse experiences early in life may sensitize the hippocampus to subsequent stressors throughout the individual's life. We analyzed in male rats, whether, the interaction between early maternal separation and chronic stress affects: (1) the volume of the dorsal hippocampus, (2) CA1, CA2/3 and dentate gyrus (DG) and (3) hippocampal-dependent memory in adulthood. Male Wistar rats were subjected to daily maternal separation for 4.5 h between postnatal days 1-21. From postnatal day 50, animals were exposed to a chronic unpredictable stress paradigm during 24 days. The volumes of the dorsal hippocampus, their areas or strata did not reveal significant differences between treatments. Non-maternally separated and stressed animals showed poor hippocampal performance in a contextual fear conditioning test, with a significant reduction in freezing behavior during post-conditioning compared with control and maternally separated and stressed animals. Also, memory retrieval 24 h after conditioning was significantly weaker in this group than in control animals. Memory performance in maternally separated and stressed rats was similar to control animals. Our results show an interaction between early environment experiences and chronic variable stress in young adulthood as evidence that early stressful experiences do not necessarily lead to a negative outcome but can help in maintaining brain plasticity and increase fitness when animals reach adulthood.

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“…unpredictable, it can also impair contextual or spatial reference memory assessed through aversive learning (Das et al, 2005;Ricon et al, 2012;Zalosnik et al, 2014).…”

Section: J U S Tmentioning

confidence: 98%

Differential effects of tianeptine on the dorsal hippocampal volume of rats submitted to maternal separation followed by chronic unpredictable stress in adulthood

Pollano

Zalosnik

Durando

et al. 2016

Stress

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Early maternal separation (MS) may produce lasting effects in the dorsal hippocampus (DH) that can change its response to chronic stress in adulthood. Chronic stress affects DH morphology and function, but tianeptine (an anti-depressant) can reverse the stress-induced morphological impairments. Morphologic alterations of hippocampus can affect contextual memory. Therefore, we evaluated the effect of tianeptine in MS and chronically stressed rats on: 1) volume of the DH and its areas using stereology and 2) hippocampal-dependent memory using a fear conditioning test. Male Wistar rats were subjected to daily MS for 4.5 h between postnatal days (PND) 1-21, or to animal facility rearing (AFR). Between (PND) days 50 and 74, rats were exposed to chronic unpredictable stress and were treated daily with tianeptine (10 mg/kg) or vehicle, providing eight groups: AFR-unstressed/vehicle (n = 5 for stereology, n = 18 for fear conditioning test); AFR unstressed/tianeptine (n = 6 and n = 10); AFR-chronic stress/vehicle (n = 6 and n = 14); AFR-chronic stress/tianeptine (n = 6 and n = 10), MS-unstressed/vehicle (n = 5 and n = 19), MS-unstressed/tianeptine (n = 6 and n = 10), MS-chronic stress/vehicle (n = 6 and n = 18), and MS-chronic stress/tianeptine (n = 6 and n = 10). MS-chronic stress/tianeptine rats showed a diminished CA1 area than the corresponding MS-unstressed/tianeptine rats. The combination of stressors produced a freezing response similar to those of the control group during postconditioning. During retrieval, MS led to a diminished freezing response compared to the AFR-unstressed groups. Tianeptine had no effect on freezing behavior. Our results show that tianeptine can affect the CA1 area volume differently depending on the nature and quantity of stressors but cannot alter freezing to context.

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Unpredictable chronic stress in juvenile or adult rats has opposite effects, respectively, promoting and impairing resilience

Cited by 50 publications

References 33 publications

Transgenerational effects of infantile adversity and enrichment in male and female rats

Transgenerational effects of infantile adversity and enrichment in male and female rats

Effect of maternal separation and chronic stress on hippocampal-dependent memory in young adult rats: evidence for the match-mismatch hypothesis

Differential effects of tianeptine on the dorsal hippocampal volume of rats submitted to maternal separation followed by chronic unpredictable stress in adulthood

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