Unprecedented highly efficient capture of glycopeptides by Fe₃O₄@Mg-MOF-74 core–shell nanoparticles

Abstract

Magnetic FeO nanospheres coated with Mg-MOF-74 have been facilely prepared via epitaxial growth. Owing to the intrinsic hydrophilic pore surface and size-exclusive properties of Mg-MOF-74, the FeO@Mg-MOF-74 core-shell nanoparticles show effective and selective enrichment of 441 N-glycosylation sites of 418 glycopeptides from 125 glycoproteins in 1 μL of human serum.

K6P2W18O62 encapsulated into magnetic Fe3O4/MIL-101 (Cr) metal–organic framework: a novel magnetically recoverable nanoporous adsorbent for ultrafast treatment of aqueous organic pollutants solutions

“…21 MOFs are a new class of nanoporous materials consisting of metal ions or clusters coordinated to organic ligands, and they have attracted considerable attention in the adsorption and removal of organic pollutants due to their ultrahigh surface areas, ultrahigh porosity, and tunable pore size. [22][23][24] Among the thousands of MOFs that have been introduced so far, one of the most prominent materials is MIL-101 (Cr). 25 MIL-101 (Cr) has been utilized as an adsorbent due to it having certain attractive features, such as large pore size, ultrahigh surface area, excellent chemical stability, and low cost.…”

Nanomaterials in Proteomics

“…Wang et al combined magnetic graphene with Zn–MOFs to fabricate MG@Zn–MOFs nanomaterials, 517 N‐glycopeptides mapped to 151 glycoproteins were identified from 1 µL of human serum . Li et al combined magnetic nanoparticles with MOF‐74 to fabricate Fe 3 O 4 @Mg–MOF‐74, 418 N‐glycopeptides of 125 glycoprotein were identified from 1 µL of human serum . Liu et al fabricated hydrophilic UiO‐66–COOH nanomaterials with binary ligands, 255 N‐glycopeptides corresponding to 93 glycoproteins were identified from 2 µL of human serum .…”

Recent Advances in Preparation and Applications of Magnetic Framework Composites

“…Conversely, it is an excellent way to add the MNPs which has been previously formed to the solution containing the inorganic metal ions and organic ligands of the desired MOFs. According to the structure of the MFCs, this idea can be divided into: embedding method, Layer‐by‐Layer (LbL) growth method and encapsulation method . Among them, the LbL method can obtain MFCs having a core–shell structure, and usually can control the size.…”

“…A nanospherical composite consisting of a Fe 3 O 4 magnetic core–shelled by Mg‐MOF‐74 (1D channel porous structure) has been facilely prepared using an epitaxial growth strategy . The Fe 3 O 4 MNPs having abundant carboxyl groups obtained by hydrothermal reaction of FeCl 3 and trisodium citrate are used for further epitaxial growth of Mg‐MOF‐74.…”