Unprecedented Case of Tumor Lysis Syndrome in a Patient With Metastatic Pancreatic Adenocarcinoma

Ling, Winnie Hui Yee; Sachdeva, Pooja; Wong, Alvin Seng Cheong; Lee, Soo‐Chin; Zee, Ying Kiat

doi:10.1097/mpa.0b013e3182327a16

Cited by 7 publications

(2 citation statements)

References 4 publications

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“…97 This patient had baseline elevation of potassium, phosphorus and LDH, however, the elevation was not high enough to meet the criteria for laboratory TLS. The patient developed TLS 2 days after the initiation of chemotherapy.…”

Section: Tumor Lysis Syndrome In Patients With Gastrointestinal Cancersmentioning

confidence: 88%

Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature

et al. 2014

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Tumor lysis syndrome (TLS) is a potentially deadly complication of tumors or their treatment. This syndrome consists of a constellation of laboratory findings such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, known as laboratory TLS. When clinical complications such as seizures, acute renal failure, and cardiac dysrhythmias occur in patients with laboratory TLS, the syndrome is called clinical TLS. TLS is especially common in patients with hematological malignancies with rapid cellular turnover rates such as acute lymphocytic leukemia and Burkitt lymphoma, but is very rare in patients with solid tumors. Nevertheless, there are multiple reports in the literature on the occurrence of TLS in patients with solid tumors. In this review article, we summarize the current data on the occurrence of TLS in patients with solid tumors. We propose an algorithm of risk stratification and prevention of TLS in patients with solid cancers.

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Section: Tumor Lysis Syndrome In Patients With Gastrointestinal Cancersmentioning

confidence: 88%

Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature

et al. 2014

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“…In pancreatic cancer TLS is rare, with only one case of TLS published, and that was in a patient who had already received chemotherapy 11. Our patient received early-directed intervention and the fatal complications of this oncological emergency were prevented.…”

Section: Discussionmentioning

confidence: 76%

A tumour lysis syndrome in a chemotherapy naïve patient with metastatic pancreatic adenocarcinoma

2015

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A 56-year-old woman with a new diagnosis of metastatic pancreatic cancer presents to the emergency room with generalised fatigue. The patient is afebrile, however, hypotensive and tachycardic. Physical examination shows diffuse lymphadenopathy. Initial laboratory tests indicate that the patient has hyperkalaemia, hypocalcaemia, with a high lactate dehydrogenase and high uric acid. The patient was also in renal failure. On the basis of the clinical presentation, the patient was diagnosed with spontaneous tumour lysis syndrome, despite the syndrome never having been reported in metastatic pancreatic cancer. The patient was treated appropriately with intravenous hydration, allopurinol and rasburicase. All laboratory abnormalities were corrected by day 3 of treatment.

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Tumor Lysis Syndrome

Gregory

Shortt

2015

Onconephrology

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Unprecedented Case of Tumor Lysis Syndrome in a Patient With Metastatic Pancreatic Adenocarcinoma

Cited by 7 publications

References 4 publications

Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature

Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature

A tumour lysis syndrome in a chemotherapy naïve patient with metastatic pancreatic adenocarcinoma

Tumor Lysis Syndrome

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