Unpleasant Sound Elicits Negative Emotion and Reinstates Drug Seeking

Chang, Suchan; Fan, Yu; Shin, Jong-Gye; Ryu, Yeonhee; Kim, Mi Seon; Steffensen, Scott C.; Kim, Hyung Kyu; Kim, Jin Mook; Lee, Bong Hyo; Jang, Eun Young; Yang, Chae Ha; Kim, Hee Young

doi:10.1007/s12035-019-1609-z

Cited by 6 publications

(3 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adult rats emit USVs in two main ranges that are thought to correspond roughly to negative and positive emotional or anticipatory states [2,4,12,13]: Lower-frequency USVs (LF; 18-30 kHz; also called "22 kHz" vocalizations) are linked to stress and fear states [14][15][16][17][18][19]; higher-frequency USVs (30-100 kHz) are linked instead to reward anticipation or experience [6][7][8][20][21][22][23]. LF vocalizations are generally not frequency-modulated,…”

Section: Introductionmentioning

confidence: 99%

Nucleus Accumbens Chemogenetic Inhibition Suppresses Amphetamine-Induced Ultrasonic Vocalizations in Male and Female Rats

et al. 2021

View full text Add to dashboard Cite

Adult rats emit ultrasonic vocalizations (USVs) related to their affective states, potentially providing information about their subjective experiences during behavioral neuroscience experiments. If so, USVs might provide an important link between invasive animal preclinical studies and human studies in which subjective states can be readily queried. Here, we induced USVs in male and female Long Evans rats using acute amphetamine (2 mg/kg), and asked how reversibly inhibiting nucleus accumbens neurons using designer receptors exclusively activated by designer drugs (DREADDs) impacts USV production. We analyzed USV characteristics using “Deepsqueak” software, and manually categorized detected calls into four previously defined subtypes. We found that systemic administration of the DREADD agonist clozapine-n-oxide, relative to vehicle in the same rats, suppressed the number of frequency-modulated and trill-containing USVs without impacting high frequency, unmodulated (flat) USVs, nor the small number of low-frequency USVs observed. Using chemogenetics, these results thus confirm that nucleus accumbens neurons are essential for production of amphetamine-induced frequency-modulated USVs. They also support the premise of further investigating the characteristics and subcategories of these calls as a window into the subjective effects of neural manipulations, with potential future clinical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Nucleus Accumbens Chemogenetic Inhibition Suppresses Amphetamine-Induced Ultrasonic Vocalizations in Male and Female Rats

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Food training and cocaine self-administration were performed in operant chambers equipped with the active and inactive levers (Med Associates, St. Albans, VT, USA) as described previously with slight modifications [40]. Initially, rats were food-restricted with 16 g of lab chow per day and trained to press the active lever to gain 45 mg food pellets (Bio-Serve, Frenchtown, NJ, USA).…”

Section: Methodsmentioning

confidence: 99%

Nociceptive stimuli activate the hypothalamus-habenula circuit to inhibit the mesolimbic reward system

Kim

Lee²,

Fan³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Nociceptive signals interact with various regions of the brain, including those involved in physical sensation, reward, cognition, and emotion. Emerging evidence points to a role of nociception in the modulation of the mesolimbic reward system. The mechanism by which nociception affects dopamine (DA) signaling and reward is unclear. The lateral hypothalamus (LH) and the lateral habenula (LHb) receive somatosensory inputs and are structurally connected with the mesolimbic DA system. Here we show that the LH-LHb pathway is necessary for nociceptive modulation of this system. Our extracellular single-unit recordings and head-mounted microendoscopic calcium imaging revealed that nociceptive stimulation by tail-pinch excited LHb and LH neurons, which was inhibited by chemical lesion of the LH. Tail-pinch decreased extracellular DA release in the nucleus accumbens ventrolateral shell, which was blocked by disruption of the LH. Furthermore, tail-pinch attenuated cocaine-induced locomotor activity, 50-kHz ultrasonic vocalizations and reinstatement of cocaine-seeking behavior, which was inhibited by chemogenetic silencing of the LH-LHb pathway. Our findings suggest that nociceptive stimulation recruits the LH-LHb pathway to inhibit mesolimbic DA system and drug reinstatement.

show abstract

“…Dopamine plays a crucial role in regulating behavior and emotions, and dopamine alteration lead to abnormal behaviors such as impulsivity and hyperactivity (Nieoullon and Coquerel, 2003;Strafella, 2019). Dysregulation of dopamine neurotransmission in dorsal striatal dopamine system is associated with the processing of negative human emotions (Badgaiyan, 2010;Chang et al, 2019). Persistent and developmental Pb exposure induces depressive behavior both in rats and children (Sciarillo et al, 1992;de Souza et al, 2005;Liu et al, 2014a,b).…”

Section: Introductionmentioning

confidence: 99%

Elevated lead levels in relation to low serum neuropeptide Y and adverse behavioral effects in preschool children with e-waste exposure

Zeng

et al. 2021

Chemosphere

View full text Add to dashboard Cite

show abstract

Unpleasant Sound Elicits Negative Emotion and Reinstates Drug Seeking

Cited by 6 publications

References 58 publications

Nucleus Accumbens Chemogenetic Inhibition Suppresses Amphetamine-Induced Ultrasonic Vocalizations in Male and Female Rats

Nucleus Accumbens Chemogenetic Inhibition Suppresses Amphetamine-Induced Ultrasonic Vocalizations in Male and Female Rats

Nociceptive stimuli activate the hypothalamus-habenula circuit to inhibit the mesolimbic reward system

Elevated lead levels in relation to low serum neuropeptide Y and adverse behavioral effects in preschool children with e-waste exposure

Contact Info

Product

Resources

About