Unpacking common and distinct neuroanatomical alterations in cocaine dependent versus pathological gambling

Irizar, Patricia; Albein‐Urios, Natalia; Martínez-González, José Miguel; Verdejo-García, Antonio; Lorenzetti, Valentina

doi:10.1016/j.euroneuro.2020.01.019

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…The importance of negative urgency in predicting classes of individuals with cocaine as the primary substance is in line with studies relating cocaine dependence severity to negative urgency (Albein-Urios et al, 2012;Cándido et al, 2012). Also, a recent study reported a significant association between the medial orbitofrontal volume and higher negative urgency, which suggests that alterations in the neural integrity within this area may drive mood-related impulsivity in cocaine-dependent individuals (Irizar et al, 2020). Impairments in neural subtracts of motor inhibition (Garavan et al, 2008), which may affect the ability of response inhibition in cocaine users (Torres et al, 2013), may also explain the observed association among fear, negative urgency, aggression-hostility, and being a member of class 4 (cocaine as primary substance, cannabis as secondary, and additional alcohol/other drugs use).…”

Section: Discussionsupporting

confidence: 70%

Clinical symptoms and personality traits predict subpopulations of treatment-seeking substance users

Martínez‐Loredo

Macipe

Errasti

et al. 2021

Journal of Substance Abuse Treatment

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Section: Discussionsupporting

confidence: 70%

Clinical symptoms and personality traits predict subpopulations of treatment-seeking substance users

Martínez‐Loredo

Macipe

Errasti

et al. 2021

Journal of Substance Abuse Treatment

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“…Although this line of research is very recent, there is already some bibliography where more activity of the right pars triangularis has been found in addictions. For example, Irizar et al (2020) has found that the right lower frontal gyrus volume (i.e., pars triangularis) was significantly larger in both the pathological gambling and cocaine dependency versus control groups. There is an abundant bibliography that links this area with mirror neurons and empathy ( Uribe et al, 2019 ; Krautheim et al, 2019 ; Rymarczyk et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

The Neurosciences of Health Communication: An fNIRS Analysis of Prefrontal Cortex and Porn Consumption in Young Women for the Development of Prevention Health Programs

et al. 2020

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This work explores the use of fNIRS neuroimaging technique using young female college students with different levels of consumption of pornography, and the activation of the prefrontal cortex (cue reactivity) when viewing a pornographic clip (cue exposure) versus a control clip. The results indicate that the viewing of the pornographic clip (vs. control clip) causes an activation of Brodmann’s area 45 of the right hemisphere (BA 45, pars triangularis) ( p < 0.01). An effect also appears between the level of self-reported consumption and the activation of right BA 45: the higher the level of self-reported consumption, the greater the activation ( p < 0.01). On the other hand, those participants who have never consumed pornographic material do not show activity of the right BA 45 compared to the control clip ( p < 0.01) indicating a qualitative difference between non-consumers and consumers. These results are consistent with other research made in the field of addictions. It is hypothesized that the mirror neuron system may be involved, through the mechanism of empathy, which could provoke vicarious eroticism. Finally, we suggest the applications that these results may have for primary and secondary prevention programs in the field of problematic consumption of pornography.

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“…All subjects were informed about the study and all provided informed consent. Data collection took place between the beginning of 2010 and the summer of 2012, and neuroimaging data from the participants included in this study using different analytical approaches have been previously reported ( Albein-Urios et al, 2014 ; Contreras-Rodríguez et al, 2015 ; Irizar, Albein-Urios, Martínez-González, Verdejo-Garcia, & Lorenzetti, 2020 ; Navas et al, 2017 ). In this study, we applied ICA and compared for the first time neural activation from the three groups (CUD, GD and HC) in the cognitive reappraisal task.…”

Section: Methodsmentioning

confidence: 99%

Brain networks alterations in cocaine use and gambling disorders during emotion regulation

Picó-Pérez

Costumero

Verdejo‐Román

et al. 2022

JBA

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Background Cocaine use disorder (CUD) and gambling disorder (GD) share clinical features and neural alterations, including emotion regulation deficits and dysfunctional activation in related networks. However, they also exhibit differential aspects, such as the neuroadaptive effects of long-term drug consumption in CUD as compared to GD. Neuroimaging research aimed at disentangling their shared and specific alterations can contribute to improve understanding of both disorders. Methods We compared CUD (N = 15), GD (N = 16) and healthy comparison (HC; N = 17) groups using a network-based approach for studying temporally coherent functional networks during functional magnetic resonance imaging (fMRI) of an emotion regulation task. We focused our analysis in limbic, ventral frontostriatal, dorsal attentional (DAN) and executive networks (FPN), given their involvement in emotion regulation and their alteration in CUD and GD. Correlations with measures of emotional experience and impulsivity (UPPS-P) were also performed. Results The limbic network was significantly decreased during emotional processing both for CUD and GD individuals compared to the HC group. Furthermore, GD participants compared to HC showed an increased activation in the ventral frontostriatal network during emotion regulation. Finally, networks' activation patterns were modulated by impulsivity traits. Conclusions Functional network analyses revealed both overlapping and unique effects of stimulant and gambling addictions on neural networks underpinning emotion regulation.

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Unpacking common and distinct neuroanatomical alterations in cocaine dependent versus pathological gambling

Cited by 10 publications

References 43 publications

Clinical symptoms and personality traits predict subpopulations of treatment-seeking substance users

Clinical symptoms and personality traits predict subpopulations of treatment-seeking substance users

The Neurosciences of Health Communication: An fNIRS Analysis of Prefrontal Cortex and Porn Consumption in Young Women for the Development of Prevention Health Programs

Brain networks alterations in cocaine use and gambling disorders during emotion regulation

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