Unnatural Amino Acids for Biological Spectroscopy and Microscopy
Ran-ran Feng,
Manxi Wang,
Wenkai Zhang
et al.
Abstract:Due to advances in methods for site-specific incorporation
of unnatural
amino acids (UAAs) into proteins, a large number of UAAs with tailored
chemical and/or physical properties have been developed and used in
a wide array of biological applications. In particular, UAAs with
specific spectroscopic characteristics can be used as external reporters
to produce additional signals, hence increasing the information content
obtainable in protein spectroscopic and/or imaging measurements. In
this Review, we summarize… Show more
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