Unmasking the human face of TB- The impact of tuberculosis on the families of patients

Goyal-Honavar, Abhijit; Markose, Annsmol P; Chhakchhuakk, Lalzikpuii; John, Sujith Mathew; Joy, Sharon A.; Kumar, Suren; Saha, Soubhik K; Palathinkal, John R; Bula, Sharon S; Yalamanchili, Sruthi; Krishna, Swathi; Jebakumar, Daniel; David, Sam Marconi; Dani, Shanti

doi:10.4103/jfmpc.jfmpc_670_20

Cited by 8 publications

(3 citation statements)

References 9 publications

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“…Enacted or experienced stigma occurs when people with TB experience stigmatizing behavior from families, communities, and healthcare workers [13]. Such stigmatizing behaviors or actions can be associated with social isolation, broken marriages, discrimination, non-disclosure of TB diagnosis, and depression [7,[14][15][16]. TB-related stigma can also hinder care-seeking behavior [17][18][19][20], delay diagnosis, and lead to adverse TB treatment outcomes including death [21].…”

Section: Introductionmentioning

confidence: 99%

Stigma, depression, and quality of life among people with pulmonary tuberculosis diagnosed through active and passive case finding in Nepal: a prospective cohort study

Dixit,

Rai,

Aryal

et al. 2024

BMC Global Public Health

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Background The psychosocial consequences of tuberculosis (TB) are key barriers to ending TB globally. We evaluated and compared stigma, depression, and quality of life (QoL) among people with TB diagnosed through active (ACF) and passive (PCF) case-finding in Nepal. Methods We prospectively recruited adults with TB diagnosed through ACF and PCF in four districts of Nepal between August 2018 and April 2019. Participants were interviewed at 8–12 weeks (baseline) and 22–26 weeks (follow-up) following treatment initiation. TB stigma was measured using an adapted Van Rie Stigma Scale (0 = no stigma to 30 = highest stigma). Depression was measured using a locally-validated Patient Health Questionnaire (PHQ-9). Mild and major depression were indicated by PHQ-9 scores 5–9 and ≥ 10, respectively. QoL was measured using the EuroQoL 5-Dimension 5-level (EQ-5D-5L) from 0 to 1 (optimal QoL); and self-rated health from 0 to 100 (optimal self-rated health). Results We recruited 221 participants (111 ACF; 110 PCF) with a mean age of 48 years (standard deviation [SD] = ± 16), of whom 147/221 (67%) were men. The mean TB stigma score was 12 (SD = 7.3) at baseline and 12 (SD = 6.7) at follow-up. The most commonly perceived elements of TB stigma at baseline were that people with TB experienced guilt (110/221, 50%) and feared disclosure outside their household (114/221, 52%). Self-rated health and EQ-5D-5L scores increased from baseline to follow-up (69.3 to 80.3, p < 0.001; 0.92 to 0.9, p = 0.009). Nearly one-third of participants (68/221, 31%) had mild or major depression at baseline. The proportion of participants with major depression decreased from baseline to follow-up (11.5% vs. 5%, p = 0.012). There was a moderate, significant positive correlation between depression and stigma scores (r = 0.41, p < 0.001). There were no differences found in TB stigma, self-rated health, QoL, or prevalence of mild/major depression between ACF and PCF participants. Conclusions We found a substantial, persistent, and clustered psychosocial impact among adults with TB diagnosed through both ACF and PCF strategies in Nepal. These findings suggest an urgent need to develop effective, evidence-based psychosocial support interventions with the potential to be integrated with existing ACF strategies and routine TB service activities.

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Section: Introductionmentioning

confidence: 99%

Stigma, depression, and quality of life among people with pulmonary tuberculosis diagnosed through active and passive case finding in Nepal: a prospective cohort study

Dixit,

Rai,

Aryal

et al. 2024

BMC Global Public Health

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“…Several publications showed that TB has a negative impact not only on the health but also on the socioeconomic of patients and families [5][6][7]. As a result, the infection makes people's environment more vulnerable and vice versa.…”

Section: Introductionmentioning

confidence: 99%

Development of Tuberculosis Vulnerability Assessment Conceptual Framework Using Automatic Content Analysis

Handayani

Hinchcliff

Hasibuan

2023

Studies in Health Technology and Informatics

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The tuberculosis prevention and control model needs to be explored. This study aimed to create a conceptual framework for measuring TB vulnerability to guide the prevention program’s effectiveness. SLR method was employed, resulting in 1.060 articles being analyzed with ACA Leximancer 5.0 and facet analysis. The built framework consists of five components: risk of TB transmission, damage caused by TB, health care facility, the burden of TB, and awareness of TB. Future research is required to explore variables in each component to formulate the degree of TB vulnerability.

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“…Importantly, TB can negatively impact on schooling, both when a child has the disease, but also when an adult family member is affected. Abhijit Goyal-Honavar et al 8 found that family with TB cases had an increased risk of financial crises and delayed and disrupted education among children. Two other studies in India found that about 10% of children with TB or with affected family members dropped out of school or could not afford books.…”

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confidence: 99%

World Tuberculosis Day: Time to Translate New Clinical Findings in Pediatric Tuberculosis in Routine Practice

Buonsenso

2023

Pediatric Infectious Disease Journal

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P ediatric tuberculosis (TB) has been historically defined a neglected-understudied-condition, despite its major impact on child health globally. In 2021, TB still affects >1 million children every year, according to the latest World Health Organization (WHO) report, and about 14% of the estimated 1.6 million deaths due to TB in 2021 involved children. 1 The reason why pediatric TB has been understudied for decades is mostly due to the paucibacillary nature of the disease, making the microbiological confirmation of the disease challenging in every setting, and specifically in lowto-middle income countries where the burden of TB is the highest. However, during the last years, more efforts have been made in studying TB in children, from diagnostics to treatments and long-term outcomes. In this commentary, the author summarizes the major results achieved in the clinical field of pediatric TB highlighting changes in practice that should be implemented immediately to improve care of these children, and other scenarios that will likely be available for implementation in the short term.Recent findings that should lead to immediate implementation of new approaches in routine clinical care are as follows:

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Unmasking the human face of TB- The impact of tuberculosis on the families of patients

Cited by 8 publications

References 9 publications

Stigma, depression, and quality of life among people with pulmonary tuberculosis diagnosed through active and passive case finding in Nepal: a prospective cohort study

Stigma, depression, and quality of life among people with pulmonary tuberculosis diagnosed through active and passive case finding in Nepal: a prospective cohort study

Development of Tuberculosis Vulnerability Assessment Conceptual Framework Using Automatic Content Analysis

World Tuberculosis Day: Time to Translate New Clinical Findings in Pediatric Tuberculosis in Routine Practice

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