2022
DOI: 10.3390/diagnostics12071742
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Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers

Abstract: The human microbiome encodes more than three million genes, outnumbering human genes by more than 100 times, while microbial cells in the human microbiota outnumber human cells by 10 times. Thus, the human microbiota and related microbiome constitute a vast source for identifying disease biomarkers and therapeutic drug targets. Herein, we review the evidence backing the exploitation of the human microbiome for identifying diagnostic biomarkers for human disease. We describe the importance of the human microbio… Show more

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Cited by 28 publications
(16 citation statements)
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“…The microbiome encodes millions of cryptic small molecules that have evolved to recognize specific cellular targets and mediate health or disease [ 40 , 41 ]. Mining these microbiome-derived molecules will lead to the discovery of unique therapeutics and diagnostic biomarkers [ 42 , 43 ]. Here, we report the discovery of lactomodulin, a new microbiome-derived molecule with dual activity as a potent anti-inflammatory and antimicrobial agent that exhibits minimal cytotoxicity in contrast to conventional antibiotics.…”
Section: Discussionmentioning
confidence: 99%
“…The microbiome encodes millions of cryptic small molecules that have evolved to recognize specific cellular targets and mediate health or disease [ 40 , 41 ]. Mining these microbiome-derived molecules will lead to the discovery of unique therapeutics and diagnostic biomarkers [ 42 , 43 ]. Here, we report the discovery of lactomodulin, a new microbiome-derived molecule with dual activity as a potent anti-inflammatory and antimicrobial agent that exhibits minimal cytotoxicity in contrast to conventional antibiotics.…”
Section: Discussionmentioning
confidence: 99%
“…Investigating the gut microbiota in relation to disease is essential for gaining insights into disease mechanisms [ 186 ], identifying biomarkers [ 187 ], developing targeted therapies [ 188 ], and advancing precision medicine [ 189 ]. However, on the other hand, the considerable proportion of studies focusing on the broader aspects of gut microbiota composition, functions, or associations rather than specific diseases reflects the growing interest in understanding the complexities of this microbial community.…”
Section: Discussionmentioning
confidence: 99%
“…Escherichia coli and Enterococcus species have also been shown to be the main bacteria associated with prostate inflammation. In recent years, many studies have investigated the role of the microbiome as a biomarker of disease [ 17 ]. The potential relevance of the urinary tract microbiome on prostate cancer diagnosis and treatment has also attracted attention, and many studies have investigated this relationship.…”
Section: Discussionmentioning
confidence: 99%