Unlocking the potential of survival data for model organisms through a new database and online analysis platform:<scp>S</scp>urv<scp>C</scp>urv

Ziehm, Matthias; Thornton, Janet M.

doi:10.1111/acel.12121

Cited by 24 publications

(15 citation statements)

References 31 publications

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“…Age‐at‐death data for the 1091 shells were collated and analysed for six common models of senescence, including a null model of no senescence (summarized in Table ). Models were fitted using the SurvCurv website (Ziehm & Thornton, ). This tool allows the calculation of the fit of a variety of models through time‐at‐death data, with a comparison of model fit using Akaike's information criterion (AIC).…”

Section: Methodsmentioning

confidence: 99%

Population‐level variation in senescence suggests an important role for temperature in an endangered mollusc

et al. 2016

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Age-related declines in survival and function (senescence) were thought not to exist in wild populations, as organisms, and particularly in invertebrates, do not live long enough. While recent evidence has demonstrated that senescence is both common and measurable even in wild populations under field conditions, there are still organisms that are thought to exhibit 'negligible senescence'. We explore variation in rates and patterns of senescence in the biogerontological model organism, the freshwater pearl mussel Margaritifera margaritifera, across five populations, which differ in their age profile. In particular, we tested the theory of negligible senescence using time-at-death records for 1091 specimens of M. margaritifera. There is clear evidence of senescence in all populations, as indicated by an increase in mortality with age, but the nature of the relationship varies subtly between populations. We find strong evidence of a mortality plateau at later ages in some populations, but this is unequivocally absent from others. We then demonstrate that the temporal scaling of the rates of senescence between five populations of M. margaritifera can be explained by the variation in the thermal environment of the population. Hence, climate change may pose a threat to the demography of this long-lived, endangered species, and a greater understanding of the relationship between river temperature and population structure will be essential to secure the species against global temperature increases. Our findings demonstrate that useful insights can be drawn from a non-invasive monitoring method to derive demographic data, and we suggest a wide-scale application of this method to monitor populations across the whole latitudinal (and, hence, thermal) range of the species.

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Section: Methodsmentioning

confidence: 99%

Population‐level variation in senescence suggests an important role for temperature in an endangered mollusc

et al. 2016

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“…Deaths were scored and losses due to causes other than death were censored. Lifespan data were deposited in SurvCurv [75] <IDs filled in proof>.…”

Section: Methodsmentioning

confidence: 99%

MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans

Riesen

Feyst²,

Rattanavirotkul³

et al. 2014

Aging

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In C. elegans, increased lifespan in daf-2 insulin/IGF-1 receptor mutants is accompanied by up-regulation of the MDL-1 Mad basic helix-loop-helix leucine zipper transcription factor. Here we describe the role of mdl-1 in C. elegans germline proliferation and aging. The deletion allele mdl-1(tm311) shortened lifespan, and did so significantly more so in long-lived daf-2 mutants implying that mdl-1(+) contributes to effects of daf-2 on lifespan. mdl-1 mutant hermaphrodites also lay increased numbers of unfertilized oocytes. During aging, unfertilized oocytes in the uterus develop into tumors, whose development was accelerated by mdl-1(tm311). Opposite phenotypes were seen in daf-2 mutants, i.e. mdl-1 and daf-2 mutant germlines are hyperplastic and hypoplastic, respectively. Thus, MDL-1, like its mammalian orthologs, is an inhibitor of cell proliferation and growth that slows progression of an age-related pathology in C. elegans (uterine tumors). In addition, intestine-limited rescue of mdl-1 increased lifespan but not to wild type levels. Thus, mdl-1 likely acts both in the intestine and the germline to influence age-related mortality.

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“…The log-rank test that was implemented in our previous version of OASIS showed that the difference between the wild-type and transgenic animals was not statistically significant ( P = 0.057; Figure 1D ). In contrast, Boschloo's test, which is implemented in OASIS 2 as well as in SurvCurv [ 5 ] and examines the differences in the proportion of longevity outliers that live beyond specific time points, detected a significant difference in maximal lifespan between the wild-type and transgenic animals ( P = 0.029; Figure 1D ). In addition, a Mann-Whitney U test, as modified by Gao and Allison [ 6 ], which was newly implemented in OASIS 2, showed that the difference in maximal lifespan was highly significant ( P = 9.0×10 −4 ; Figure 1D ).…”

Section: Resultsmentioning

confidence: 99%

OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research

et al. 2016

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Unlocking the potential of survival data for model organisms through a new database and online analysis platform:SurvCurv

Cited by 24 publications

References 31 publications

Population‐level variation in senescence suggests an important role for temperature in an endangered mollusc

Population‐level variation in senescence suggests an important role for temperature in an endangered mollusc

MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans

OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research

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