Unlocking the potential of non-coding RNAs in cancer research and therapy

Uppaluri, Kalyan Ram; Challa, Hima J; Gaur, Ashish; Jain, Rajul; Krishna Vardhani, K; Geddam, Anusha; Natya, K; Aswini, K; Palasamudram, Kalyani; K, Sri Manjari

doi:10.1016/j.tranon.2023.101730

Cited by 9 publications

(3 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the basis of size, ncRNAs can be classified as long ncRNAs (lncRNAs) (>200 nucleotides (nt)) and small ncRNAs (<200 nt) (Uppaluri et al, 2023). lnccoding RNAs are characterized as untranslated RNAs comprised of two subgroups called circRNAs and pseudogenes (Zhang et al, 2019).…”

Section: Overview and Classification Of Ncrnasmentioning

confidence: 99%

“…lncRNAs may or may not have a cap, contributing to their diverse functions in gene regulation and cellular processes. tRNAs are generally uncapped, relying on post-transcriptional modifications for their crucial role in translation (Uppaluri et al, 2023).…”

Section: Overview and Classification Of Ncrnasmentioning

confidence: 99%

“…Despite these challenges, understanding and harnessing ncRNA potential in cancer holds promise for improved diagnostic and therapeutic interventions. However, obstacles like lack of specificity and limited mechanistic understanding remain significant barriers (Di Leva & Croce, 2013; Uppaluri et al, 2023).…”

Section: Diagnostic and Therapeutic Implicationsmentioning

confidence: 99%

See 2 more Smart Citations

Untitled

2024

SciRevs.Biology

View full text Add to dashboard Cite

Cancer is among one of the most widespread diseases globally and poses a great threat to human wellbeing. Non-coding RNAs (ncRNAs) compose most transcripts but cannot undergo translation. Thus, no proteins are made by them. However, studies have shown that ncRNAs can mimic both oncogenes and tumour suppressor genes involved in cancer. This review discusses recent research on the involvement of ncRNAs in the progression, diagnosis, and treatment of cancer. These ncRNAs consist of microRNAs, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). This concise paper aims to inform researchers, clinicians, and scientists in navigating the dynamic field of ncRNAs in cancer with the goal of fostering collaboration to translate discoveries into practical clinical advancements.

show abstract

Section: Overview and Classification Of Ncrnasmentioning

confidence: 99%

Section: Overview and Classification Of Ncrnasmentioning

confidence: 99%