Unlocking the potential of Mesenchymal stem cells in liver Fibrosis: Insights into the impact of autophagy and aging

Tao, Hongxia; Liu, Qianglin; Zeng, Anqi; Song, Linjiang

doi:10.1016/j.intimp.2023.110497

Cited by 2 publications

(1 citation statement)

References 130 publications

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“…The efficacy of MSCs as a therapeutic intervention is contingent upon the maintenance of optimal levels of autophagy, which in turn can ameliorate the fibrotic cascade. Despite this, aging-related autophagic damage is associated with a decline in MSC number and function, which are crucial to liver fibrosis ( 82 ).…”

Section: Liver Cirrhosis Immune Microenvironmentmentioning

confidence: 99%

Immune microenvironment changes of liver cirrhosis: emerging role of mesenchymal stromal cells

Yang

Wang

et al. 2023

Front. Immunol.

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Cirrhosis is a progressive and diffuse liver disease characterized by liver tissue fibrosis and impaired liver function. This condition is brought about by several factors, including chronic hepatitis, hepatic steatosis, alcohol abuse, and other immunological injuries. The pathogenesis of liver cirrhosis is a complex process that involves the interaction of various immune cells and cytokines, which work together to create the hepatic homeostasis imbalance in the liver. Some studies have indicated that alterations in the immune microenvironment of liver cirrhosis are closely linked to the development and prognosis of the disease. The noteworthy function of mesenchymal stem cells and their paracrine secretion lies in their ability to promote the production of cytokines, which in turn enhance the self-repairing capabilities of tissues. The objective of this review is to provide a summary of the alterations in liver homeostasis and to discuss intercellular communication within the organ. Recent research on MSCs is yielding a blueprint for cell typing and biomarker immunoregulation. Hopefully, as MSCs researches continue to progress, novel therapeutic approaches will emerge to address cirrhosis.

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Section: Liver Cirrhosis Immune Microenvironmentmentioning

confidence: 99%