Unlocking the Potential of Adequate Bacillus Calmette-Guérin Immunotherapy in Very-high-risk Non–muscle-invasive Bladder Carcinoma: A Multicenter Analysis of Oncological Outcomes and Risk Dynamics

Subiela, José Daniel; Krajewski, Wojciech; González-Padilla, Daniel A.; Laszkiewicz, Jan; Taborda, Javier; Aumatell, Júlia; Sanchez Encinas, Miguel; Basile, Giuseppe; Moschini, Marco; Caño-Velasco, Jorge; Lopez Perez, Enrique; Del Olmo Durán, Pedro; Gallioli, Andrea; Tukiendorf, Andrzej; D'Andrea, David; Yuen-Chun Teoh, Jeremy; Serna Céspedes, Alejandra; Pichler, Renate; Afferi, Luca; Del Giudice, Francesco; Gomez Rivas, Juan; Albisinni, Simone; Soria, Francesco; Ploussard, Guillaume; Mertens, Laura S.; Rajwa, Paweł; Laukhtina, Ekaterina; Pradere, Benjamin; Tully, Karl; Guerrero-Ramos, Félix; Rodríguez-Faba, Óscar; Alvarez-Maestro, Mario; Dominguez-Escrig, Jose Luis; Szydełko, Tomasz; Gomez Dos Santos, Victoria; Jiménez Cidre, Miguel Ángel; Burgos Revilla, Francisco Javier

doi:10.1016/j.euo.2024.01.017

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…Intravesical BCG injection therapy has a very strong prognostic effect on the recurrence of NMIBC [14]. However, even in situations where the risk classification indicates that intravesical BCG injection therapy should be performed, there are cases in which this treatment is not possible.…”

Section: Introductionmentioning

confidence: 99%

Association Between Residual Urine Volume and Recurrence Among Patients at High Risk of Non-Muscle-Invasive Bladder Carcinoma With Versus Without Bacillus Calmette-Guérin Treatment

Murakami,

Sazuka,

Tsukamoto

et al. 2024

Cureus

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Non-muscle-invasive bladder carcinoma often occurs in older adults, who often also have urinary dysfunction. The residual urine volume is an important indicator of urinary dysfunction. However, the impact of the residual urine volume on intravesical recurrence remains unclear. In the present study, we analyzed the data of 372 patients at high or very high risk of cancer progression according to the Japanese Urological Association classification who had undergone transurethral resection of a bladder tumor. In univariate analysis, postoperative absence of intravesical Bacillus Calmette-Guérin (BCG) induction was an independent risk factor for intravesical recurrence (hazard ratio 1.94, absence versus presence, p = 0.0019). The incidence of intravesical recurrence did not significantly differ between the mild, intermediate, and severe residual urine groups in the total cohort. Among the BCG-treated cohort, the three groups showed similar trends. Among the non-BCG-treated cohort, although the patients with more than 100 ml of residual urine tended to have more intravesical recurrence than patients with a smaller residual urine volume, this difference did not reach statistical significance. BCG treatment is recommended for patients at high risk of bladder carcinoma. Patients with a large residual urine volume without BCG treatment may be at high risk of intravesical recurrence.

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Section: Introductionmentioning

confidence: 99%

Association Between Residual Urine Volume and Recurrence Among Patients at High Risk of Non-Muscle-Invasive Bladder Carcinoma With Versus Without Bacillus Calmette-Guérin Treatment

Murakami,

Sazuka,

Tsukamoto

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

Implementación de los nuevos tratamientos para el tumor vesical no músculo invasivo que no responde al tratamiento con BCG. Aspectos a considerar en Latinoamérica

Fernández

2024

Actas Urológicas Españolas

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Implementation of new treatments for BCG-unresponsive non-muscle-invasive bladder cancer. Considerations in Latin America

Fernández

2024

Actas Urológicas Españolas (English Edition)

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Unlocking the Potential of Adequate Bacillus Calmette-Guérin Immunotherapy in Very-high-risk Non–muscle-invasive Bladder Carcinoma: A Multicenter Analysis of Oncological Outcomes and Risk Dynamics

Cited by 5 publications

References 16 publications

Association Between Residual Urine Volume and Recurrence Among Patients at High Risk of Non-Muscle-Invasive Bladder Carcinoma With Versus Without Bacillus Calmette-Guérin Treatment

Association Between Residual Urine Volume and Recurrence Among Patients at High Risk of Non-Muscle-Invasive Bladder Carcinoma With Versus Without Bacillus Calmette-Guérin Treatment

Implementación de los nuevos tratamientos para el tumor vesical no músculo invasivo que no responde al tratamiento con BCG. Aspectos a considerar en Latinoamérica

Implementation of new treatments for BCG-unresponsive non-muscle-invasive bladder cancer. Considerations in Latin America

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