Unlocking The Mysteries of DNA Adducts with Artificial Intelligence
Sakshi Arora,
Shiva Satija,
Aayushi Mittal
et al.
Abstract:Cellular genome is considered a dynamic blueprint of a cell since it encodes genetic information that gets temporally altered due to various endogenous and exogenous insults. Largely, the extent of genomic dynamicity is controlled by the trade‐off between DNA repair processes and the genotoxic potential of the causative agent (genotoxins or potential carcinogens). A subset of genotoxins form DNA adducts by covalently binding to the cellular DNA, triggering structural or functional changes that lead to signific… Show more
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