Unlocking prophage potential:In silicoand experimental analysis of a novelMycobacterium fortuitumLysinB containing a peptidoglycan-binding domain
Ritam Das,
Kanika Nadar,
Ritu Arora
et al.
Abstract:Endolysins are highly evolved bacteriophage-encoded lytic enzymes produced to damage the bacterial cell wall for phage progeny release. They offer promising potential as highly specific lytic proteins with a low chance of bacterial resistance. The diversity in lysin sequences and domain organization can be staggering. In silico analysis of bacteriophage and prophage genomes can help identify endolysins exhibiting unique features and high antibacterial activity, hence feeding the pipeline of narrow-spectrum pro… Show more
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