Unlocking Antibacterial Potential: Key-Site-Based Regulation of Antibacterial Spectrum of Peptides
Wanpeng Wu,
Jing Song,
Tong Li
et al.
Abstract:In the pursuit of combating multidrug-resistant bacteria, antimicrobial peptides (AMPs) have emerged as promising agents; however, their application in clinical settings still presents challenges. Specifically, the exploration of crucial structural parameters that influence the antibacterial spectrum of AMPs and the subsequent development of tailored variants with either broador narrow-spectrum characteristics to address diverse clinical therapeutic needs has been overlooked. This study focused on investigatin… Show more
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