Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
Thomas Wharton,
Felicity Crawshay‐Williams,
Tim Schober
et al.
Abstract:The controlled liberation of molecules from a constructed framework is a subject of profound interest across various chemical fields. It allows for the masking of a molecule's properties and precise deployment upon a single controllable release event. While numerous methodologies have been developed for amines, alcohols, and thiols, approaches for utilising amides as payload‐release handles are still in their early stages of development, despite the prevalence of amides in therapeutic compounds and materials. … Show more
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