Unlike Effects of Denervation on the Rate of Entry of Inorganic Phosphate Into Rat Slow and Fast Muscles

Abstract

The increased inorganic phosphate flow, characteristic of denervated gastrocnemius muscle is shown to be present in additional denervated fast muscles, i.e. the plantaris, tibialis anterior and extensor digitorum longus muscles. The response of the soleus, a slow muscle, to denervation is biphasic. After an initial decrease of the phosphate flow at the end of the first postoperative day, there is a secondary rise which has the same general characteristics as the rise observed in fast muscles i.e. an exponential or hyperbolic increase to an asymptotic value reached after thirty days. The denervated fast and slow muscles are not converging to an intermediate metabolic pattern. The changes in phosphate flow induced by denervation are reversible in the soleus as well as in the gastrocnemius muscles.

Nerve and Muscle Regeneration after Axonal Division in Rats Treated with Isaxonine Phosphate (Isopropylamino-2-Pyrimidine Phosphate)

“…Daily isaxonine phosphate dosage does not interfere with the increase in radiophosphate uptake character istic of denervated muscle [8] -in some cases it is even higher than in the normal saline controls -nor does it accelerate the return to normal: after the 14th day in the gastrocne mius, after the 21 st day in the soleus (tables I.…”

Sutures or fibrin glue for divided rat nerves: Schwann cell and muscle metabolism

“…After an initial decrease of the phosphate flow at the end of the first postoperative day, there is a secondary rise which has the same general characteristics as the one observed in fast muscle^.^ When the motor denervation is consequent on a nerve crush, the changes induced by denervation are largely reversible in both gastrocnemius and soleus muscles upon functional reinnervation, the slight deviation from normal being explained by a certain degree of cross-reinnervation. 1,4,5 In this paper, we present the results of an experimental study in the rat, documenting the time effects of a microsurgical suture technique and comparing the long-term results of primary repair after either stitching microsurgically or glueing together the divided ends of the sciatic nerve.…”