Unleashing the power from commercial off-the-shelf ion mobility spectrometer

Tam, Maggie; Maheux, Chad R.; Lalonde, Steven; Binette, Marie-Josée

doi:10.1007/s12127-019-00245-z

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…Previous studies have demonstrated the effectiveness of using standalone IM for the study of fentanyl analogs yielding results in real time with nanogram‐level sensitivity 12,40–48 . These findings highlight the potential of IM as a powerful analytical tool for detecting trace amounts of fentanyl analogs in complex sample matrices.…”

Section: Introductionmentioning

confidence: 67%

“…32,38,39 Previous studies have demonstrated the effectiveness of using standalone IM for the study of fentanyl analogs yielding results in real time with nanogram-level sensitivity. 12,[40][41][42][43][44][45][46][47][48] These findings highlight the potential of IM as a powerful analytical tool for detecting trace amounts of fentanyl analogs in complex sample matrices. However, these approaches have been limited to screening due to their inability to differentiate between compounds with very similar chemical structures and reduced mobility values.…”

mentioning

confidence: 83%

“…These findings highlight the potential of IM as a powerful analytical tool for detecting trace amounts of fentanyl analogs in complex sample matrices. However, these approaches have been limited to screening due to their inability to differentiate between compounds with very similar chemical structures and reduced mobility values 40–48 . Metternich et al reported challenges in using mobile/portable IMS in detecting fentanyl and buprenorphine in highly viscous matrices such as toothpaste or liquid soap due to the poor solubility and inhomogeneous distribution of the analytes in the products and limited selectivity of that instrumentation 45 .…”

Section: Introductionmentioning

confidence: 99%

“…However, these approaches have been limited to screening due to their inability to differentiate between compounds with very similar chemical structures and reduced mobility values. [40][41][42][43][44][45][46][47][48] Metternich et al reported challenges in using mobile/portable IMS in detecting fentanyl and buprenorphine in highly viscous matrices such as toothpaste or liquid soap due to the poor solubility and inhomogeneous distribution of the analytes in the products and limited selectivity of that instrumentation. 45 However, such scenarios would be more easily overcome when using a combination of laboratory sample preparation methods (i.e., extraction/purification) and chromatographic separations prior to IM analysis (i.e., LC-IM-MS).…”

mentioning

confidence: 99%

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Improved separation of fentanyl isomers using metal cation adducts and high‐resolution ion mobility‐mass spectrometry

Aderorho,

Chouinard

2023

Drug Testing and Analysis

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Fentanyl is a potent synthetic opioid that has attracted significant attention due to its illegal production and distribution, resulting in misuse, overdose, and fatalities. Because numerous fentanyl analogs, including structural isomers, with different potency have been discovered in the field, there is a critical need to continue developing analytical methodologies capable of accurate identification in forensic and clinical laboratories. This study aimed to develop a rapid method for detecting and separating fentanyl isomers based on ion mobility–mass spectrometry (IM‐MS), where IM separates gas‐phase ions based on differences in their size, shape, and charge. Several strategies for improved differentiation were implemented, including using unconventional cation adducts (e.g., alkali and transition metals) and data post‐processing by high‐resolution demultiplexing. A collection of collision cross section (CCS) values for the various metal ion adducts was gathered, which can be used to improve confidence of identification in future samples. Notable examples, such as [M + Cu]+ and [M + Ag]+ adducts, contributed to significant improvement of resolution between isomers. Furthermore, the addition of high‐resolution post‐processing provided resolving power of >150, which constitutes a significant increase in comparison with the normal 50–60 obtained with low‐resolution drift tube instruments. Collectively, these improved separation strategies allowed for confident detection and subsequent quantitative analysis. The optimized IM‐MS method resulted in quantification of fentanyl in human urine with limits of detection and quantification of 13 pg/mL and 40 pg/mL, respectively.

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Section: Introductionmentioning

confidence: 67%

mentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Improved separation of fentanyl isomers using metal cation adducts and high‐resolution ion mobility‐mass spectrometry

Aderorho,

Chouinard

2023

Drug Testing and Analysis

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Ion Mobility Spectrometry in Forensic Science

Joshi

2024

Encyclopedia of Analytical Chemistry

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Ion mobility spectrometry ( IMS ) is a valuable screening technique for hazardous chemicals in the field. It is prolifically used by law enforcement agencies, emergency response personnel, security agencies, and the military to detect explosives, illicit drugs, toxic industrial chemicals, and chemical warfare agents. IMS has been greatly successful, thanks to its portability, ruggedness, ability to operate at ambient pressures, low power requirements, simplicity, fast analysis times, and excellent sensitivity to target substances. This article outlines the current status of IMS and explores exciting innovations that could bring mobility principles to the laboratory, potentially improving the efficiency and accuracy of chemical analyses. The growth of gas chromatography‐ion mobility spectrometry ( GC–IMS ) and ion mobility‐mass spectrometry ( IM–MS ) could be an avenue for exploration in forensic science analysis. Both techniques improve upon IMS by addressing its weaknesses of poor resolution and susceptibility to mixtures. These are the primary obstacles to the laboratory use of IMS. As IMS continues to serve as a trace chemical monitor in the field, these developments in the coupling of IMS principles with other analytical techniques are giving mobility spectrometry a new purpose in the laboratory.

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