Unleashing the Potential of Camptothecin: Exploring Innovative Strategies for Structural Modification and Therapeutic Advancements

Abstract

t 1/2 α, alpha half-life; t 1/2 β, beta half-life; AUC, area under the concentration−time curve; CL, clearance; Vd ss , volume of distribution at steady state; LD 50 , the median lethal dose that causes 50% mortality in tested animals after a specified test duration.