University Spinoffs: What, Why, and How?

Pattnaik, Pinaki Nandan; Pandey, Satyendra C.

doi:10.22215/timreview/857

Cited by 34 publications

(8 citation statements)

References 18 publications

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“…Large pharmaceutical enterprises tend to be risk-aversive in their research and development programs and take up product-commercialization processes only at advanced stages. It is, thus, often left to research institutions and small spin-off and start-up companies to take on the early, risky steps of drug development, including production optimization, safety assessment, and first clinical trials [128,129]. To improve microbial-driven production processes, the following areas (summarized in Figure 6) need investment from research institutions and companies alike.…”

Section: Optimization Of Bioactive Compound Production To Meet Indmentioning

confidence: 99%

Bioactive Secondary Metabolites from Octocoral-Associated Microbes—New Chances for Blue Growth

et al. 2018

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Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical diversity of octocorals is yet to be achieved. This review inventories the natural products so-far described for octocoral-derived bacteria and fungi, uncovering a true chemical arsenal of terpenes, steroids, alkaloids, and polyketides with antibacterial, antifungal, antiviral, antifouling, anticancer, anti-inflammatory, and antimalarial activities of enormous potential for blue growth. Genome mining of 15 bacterial associates (spanning 12 genera) cultivated from Eunicella spp. resulted in the identification of 440 putative and classifiable secondary metabolite biosynthetic gene clusters (BGCs), encompassing varied terpene-, polyketide-, bacteriocin-, and nonribosomal peptide-synthase BGCs. This points towards a widespread yet uncharted capacity of octocoral-associated bacteria to synthetize a broad range of natural products. However, to extend our knowledge and foster the near-future laboratory production of bioactive compounds from (cultivatable and currently uncultivatable) octocoral symbionts, optimal blending between targeted metagenomics, DNA recombinant technologies, improved symbiont cultivation, functional genomics, and analytical chemistry are required. Such a multidisciplinary undertaking is key to achieving a sustainable response to the urgent industrial demand for novel drugs and enzyme varieties.

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Section: Optimization Of Bioactive Compound Production To Meet Indmentioning

confidence: 99%

Bioactive Secondary Metabolites from Octocoral-Associated Microbes—New Chances for Blue Growth

et al. 2018

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“…"University spin-offs have remarkably strengthened the linkage between universities and industry. The number of technology patents and spin-offs coming out of university research has a significant impact on regional economic and social development" [47]. In this context, it will be interesting to consider the views of many authors [48][49][50][51][52][53][54][55][56].…”

Section: Entrepreneurial University: a Brief Literature Reviewmentioning

confidence: 99%

Effectiveness of entrepreneurial universities: experiences and challenges in digital era (a systemic approach)

Dominici¹,

Gagnidze²

2021

Interdiscip. Descr. Complex Syst.

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The modern world actively discusses the challenges that will lead to the Fourth Industrial Revolution. As the specialists assume, part of the jobs will be replaced by artificial intelligence. In addition, creation of completely new jobs is expected. As for the jobs that might be maintained in future, skills upgrading will be particularly important.In such a turbulent environment of economic development, universities, and in particular entrepreneurial universities, play a significant role. We think so as these universities have special structures that promote form a university-industry-government triple helix, reskilling and commercialization of new ideas, etc. Due to the above-mentioned factors, they will neutralize the expected fluctuations in the best way. Later we will discuss the systemic links between the mutual influence of entrepreneurial universities and economy. We consider that continuous connection with such universities will enable business to adapt to the inevitable changes with minimal loss.

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“…As a first point, spin-out Company working definition had to be established. This was done by looking at several authors that made attempts to define the concept of a spin-out company within the context of publicly funded R&D (Pirnay et al, 2003;Borges and Fillion, 2013;Pattnaik and Pandey, 2014). In defining the concept, there appears to be a pattern which reflects that the definition of a spin-out company is sometimes interchangeably defined with other concepts such as spin-off companies or university start-ups or academic enterprises.…”

Section: Literature Reviewmentioning

confidence: 99%

“…In their paper titled toward a typology of University Spin-off, Pirnay et al (2003) define spin-off companies as "new firms created to exploit commercially some knowledge, technology or research results developed within a university." Pattnaik and Pandey, (2014) have made their contribution to the academic spin-out company definition by stating that its characteristics are as follows: Firstly the parent organisation from which the innovation emerges has to be a university or academic institution, secondly the output that is a university spin-out has to be a separate legal entity which is not an extension or controlled body of the university, thirdly the new entity has to exploit knowledge produced from academic activities or academic pursuits and fourthly the spin-out company should be aimed at profit generation and commercialisation of technology.…”

Section: Literature Reviewmentioning

confidence: 99%

Success Factors for Creating Spin-Out Companies by South African Publicly Financed Research and Development Institutions: A Resource-Based View Perspective

Langa¹,

Edoun²,

Naidoo³

2018

JEBS

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Technology commercialisation using spin-out companies has shown to be a viable option by publicly financed research and development (R&D) institutions internationally. In South Africa (SA) this trend of spin-out company creation for technology commercialisation is anticipated to be on the rise since the inception of the Intellectual Property Rights from Publicly Financed Research and Development Act number 51 of 2008 (IPR-PFRD Act). This study aimed at trying to understand the factors that influence the successful creation of spin-out companies by SA publicly financed R&D institutions, utilising the RBV as the main theoretical framework. A survey questionnaire was distributed using a purposive sample approach to 49 key individuals (technology transfer professionals) who have been involved in spin-out creation in the past and the response was received from 17 respondents. A mixed methods research methodology was utilised and the data was presented using descriptive statistics and narration. The results of the data indicate a similar pattern to international trends and in some instances unique resource combinations that are relevant to SA. Questionnaire:The data collection instrument consisted of questions (open-ended and close-ended) assessing different aspects relating to respondents deemed success factors in the spin-out company creations

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University Spinoffs: What, Why, and How?

Cited by 34 publications

References 18 publications

Bioactive Secondary Metabolites from Octocoral-Associated Microbes—New Chances for Blue Growth

Bioactive Secondary Metabolites from Octocoral-Associated Microbes—New Chances for Blue Growth

Effectiveness of entrepreneurial universities: experiences and challenges in digital era (a systemic approach)

Success Factors for Creating Spin-Out Companies by South African Publicly Financed Research and Development Institutions: A Resource-Based View Perspective

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