University of Washington Alzheimer’s Disease Patient Registry (ADPR): 1987–8

Larson, Eric B.; Kukull, Walter A.; Teri, Linda; McCormick, Wayne C.; Pfanschmidt, Meredith L.; Belle, Gerald van; Sumi, Masahiko

doi:10.1007/bf03323960

Cited by 52 publications

(66 citation statements)

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“…Subjects with dementia were enrolled in 1 of 7 Alzheimer disease centers (ADCs) (Oregon Health and Science University; Rush University Medical Center; University of California, San Diego; University of Kentucky; University of Pennsylvania; University of Pittsburgh; and University of Washington), in the Rush Memory and Aging Project, or in the Group Health/ University of Washington Alzheimer's Disease Patient Registry/ Adult Changes in Thought Study. The Group Health/University of Washington Alzheimer's Disease Patient Registry/Adult Changes in Thought Study is a community-based longitudinal study that enrolled individuals aged 65 years or older with dementia 6 or with no dementia 7 from a health maintenance organization in the Seattle area. Expert diagnosticians at the ADCs, Rush Memory and Aging Project, and Group Health/University of Washington Alzheimer's Disease Patient Registry/Adult Changes in Thought Study reviewed subject clinical history, physical examinations, and neuropsychological tests at a consensus diagnosis conference.…”

Section: Methods Subjects and Clinical Evaluationmentioning

confidence: 99%

GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology

et al. 2012

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Objectives: Mutations in the GBA gene occur in 7% of patients with Parkinson disease (PD) and are a well-established susceptibility factor for PD, which is characterized by Lewy body disease (LBD) neuropathologic changes (LBDNCs). We sought to determine whether GBA influences risk of dementia with LBDNCs, Alzheimer disease (AD) neuropathologic changes (ADNCs), or both. Methods:We screened the entire GBA coding region for mutations in controls and in subjects with dementia and LBDNCs and no or low levels of ADNCs (pure dementia with Lewy bodies [pDLB]), LBDNCs and high-level ADNCs (LBD-AD), and high-level ADNCs but without LBDNCs (AD).Results: Among white subjects, pathogenic GBA mutations were identified in 6 of 79 pDLB cases (7.6%), 8 of 222 LBD-AD cases (3.6%), 2 of 243 AD cases (0.8%), and 3 of 381 controls (0.8%). Subjects with pDLB and LBD-AD were more likely to carry mutations than controls (pDLB: odds ratio [OR] ϭ 7.6; 95% confidence interval [CI] ϭ 1.8-31.9; p ϭ 0.006; LBD-AD: OR ϭ 4.6; CI ϭ 1.2-17.6; p ϭ 0.025), but there was no significant difference in frequencies between the AD and control groups (OR ϭ 1.1; CI ϭ 0.2-6.6; p ϭ 0.92). There was a highly significant trend test across groups ( 2 (1) ϭ 19.3; p ϭ 1.1 ϫ 10 Ϫ5 ), with the likelihood of carrying a GBA mutation increasing in the following direction: control/AD Ͻ LBD-AD Ͻ pDLB. Conclusions:GBA is a susceptibility gene across the LBD spectrum, but not in AD, and appears to convey a higher risk for PD and pDLB than for LBD-AD. PD and pDLB might be more similar to one another in genetic determinants and pathophysiology than either disease is to LBD-AD.

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Section: Methods Subjects and Clinical Evaluationmentioning

confidence: 99%

GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology

et al. 2012

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“…13 The primary goal of the registry was to enroll all patients detected by their primary care physicians or other providers to have new dementia symptoms or complaints (e.g., memory loss, confusion, wandering). Each patient identified by the ADPR was given a complete, standardized physical, neurologic, and neuropsychological examination.…”

Section: Study Populationmentioning

confidence: 99%

Characteristics of Sleep Disturbance in Community-Dwelling Alzheimer's Disease Patients

McCurry¹,

Logsdon²,

Teri³

et al. 1999

J Geriatr Psychiatry Neurol

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159

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This study examined the frequency, predictors, and impact of sleep problems in a population-based sample of 205 Alzheimer's disease (AD) patients. Sleeping more than usual and early morning awakenings were the most common sleep problems reported but were the least disturbing behaviors for caregivers. Night-time awakenings were less common but were most disturbing to caregivers. Using logistic regression analyses, the factors most strongly associated with night awakenings among patients were male gender, greater memory problems, and decreased functional status. Patient depression increased the risk for caregivers to rate patient sleep problems as more disturbing overall. Cluster analyses revealed three characteristic groups of patients who awakened caregivers: one group was inactive during the day but had few other behavior problems; one group had increased levels of fearfulness, fidgeting, and occasional sadness; and the third group had multiple behavior problems, including frequent episodes of sadness, fearfulness, inactivity, fidgeting, and hallucinations. These findings indicate that the nature of sleep problems in AD is multifaceted; future research on the occurrence and treatment of sleep disturbance in dementia patients should consider the patterns of individual differences that may influence its development.

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“…Subjects were identi®ed during the enrollment phase of a community-based prospective cohort study of dementia and normal ageing (`Adult Changes of Thought' or ACT study) being conducted collaboratively between the University of Washington and Group Health Cooperative (GHC), a major health maintenance organization in Seattle (Larson et al, 1990). Between March 1994 and April 1996, a sample of 6782 individuals over age 65 was randomly selected from the GHC registry.…”

Section: Study Populationmentioning

confidence: 99%

The cognitive abilities screening instrument (CASI): data from a cohort of 2524 cognitively intact elderly

McCurry

Edland

Teri

et al. 1999

Int. J. Geriat. Psychiatry

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Objectives To describe the effects of age and education for the Cognitive Abilities Screening Instrument (CASI), a 25‐item test of cognitive function. Design Cross‐sectional descriptive study of the initial enrollment in a community‐based prospective cohort study. Participants A total of 2524 cognitively intact older adults over age 65 who were members of a major health maintenance organization, and who consented to participate in a longitudinal study. Measurements Summary scores for the CASI are given in the form of mean, median and percentile distributions specific for age and educational level. Results Based upon maximum likelihood analyses, age and education were significant (p<0.0001) predictors of total CASI score. Increased age and lower education were associated with a lower CASI score, as well as an increased spread in score distribution. Gender was also significantly related (p<0.01) to total CASI, with women having a slightly higher distribution of scores. Mean total scores ranged from CASI=82.2 (SD=9.0) in subjects aged 90–95 who had less than a high school degree to CASI=94.8 (SD=3.8) in subjects aged 65–69 with at least a high school education. Conclusions Like most cognitive screening instruments, performance on the CASI in non‐demented persons is influenced by age and education. The reference values for 5‐year age categories described in this article should be useful for clinicians and research investigators when using the CASI as a measure of cognitive function. Copyright © 1999 John Wiley & Sons, Ltd.

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University of Washington Alzheimer’s Disease Patient Registry (ADPR): 1987–8

Cited by 52 publications

References 0 publications

GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology

GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology

Characteristics of Sleep Disturbance in Community-Dwelling Alzheimer's Disease Patients

The cognitive abilities screening instrument (CASI): data from a cohort of 2524 cognitively intact elderly

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