We consider a class of kinetically constrained interacting particle systems on Z d which play a key role in several heuristic qualitative and quantitative approaches to describe the complex behavior of glassy dynamics. With rate one and independently among the vertices of Z d , to each occupation variable ηx ∈ {0, 1} a new value is proposed by tossing a (1 − q)-coin. If a certain local constraint is satisfied by the current configuration the proposed move is accepted, otherwise it is rejected. For d = 1, the constraint requires that there is a vacancy at the vertex to the left of the updating vertex. In this case, the process is the well-known East process. On Z 2 , the West or the South neighbor of the updating vertex must contain a vacancy, similarly, in higher dimensions. Despite of their apparent simplicity, in the limit q ց 0 of low vacancy density, corresponding to a low temperature physical setting, these processes feature a rather complicated dynamic behavior with hierarchical relaxation time scales, heterogeneity and universality. Using renormalization group ideas, we first show that the relaxation time on Z d scales as the 1/d-root of the relaxation time of the East process, confirming indications coming from massive numerical simulations. Next, we compute the relaxation time in finite boxes by carefully analyzing the subtle energy-entropy competition, using a multiscale analysis, capacity methods and an algorithmic construction. Our results establish dynamic heterogeneity and a dramatic dependence on the boundary conditions. Finally, we prove a rather strong anisotropy property of these processes: the creation of a new vacancy at a vertex x out of an isolated one at the origin (a seed) may occur on (logarithmically) different time scales which heavily depend not only on the ℓ1-norm of x but also on its direction. . This reprint differs from the original in pagination and typographic detail. 1 2 P. CHLEBOUN, A. FAGGIONATO AND F. MARTINELLI 1. Introduction. The East process is a one-dimensional spin system introduced in the physics literature by Jäckle and Eisinger [29] in 1991 to model the behavior of cooled liquids near the glass transition point, specializing a class of models that goes back to [2]. Each site x ∈ Z carries a {0, 1}-value (vacant/occupied) denoted by η x . The process attempts to update η x to 1 at rate 0 < p < 1 (a parameter) and to 0 at rate q = 1 − p, only accepting the proposed update if η x−1 = 0 (a "kinetic constraint"). Since the constraint at site x does not depend on the spin at x, it is straightforward to verify that the product Bernoulli(1 − q) measure is a reversible measure.Despite of its apparent simplicity, the East model has attracted much attention both in the physical and in the mathematical community (see, e.g., [1,16,21,34,35]). It in fact features a surprisingly rich behavior, particularly when q ≪ 1 which corresponds to a low temperature setting in the physical interpretation, with a host of phenomena like mixing time cutoff and front propagation [6,23], hierarch...