Universal, untargeted detection of bacteria in human tissues using spatial metabolomics
Wei Chen,
Min Qiu,
Petra Paizs
et al.
Abstract:Fast and reliable identification of bacteria directly in clinical samples is the holy grail of microbiological diagnostics. Current approaches predominantly require time-consuming bacterial isolation and enrichment procedures, delaying stratified treatment. Here, we describe a biomarker-based, hierarchical strategy that utilises conserved bacterial small molecular metabolites and lipids for direct mass spectrometric detection of bacteria in clinical samples. Marker discovery was carried out by creating a metab… Show more
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