Universal polymer coatings and their representative biomedical applications

Wei, Qiang; Haag, Rainer

doi:10.1039/c5mh00089k

Cited by 212 publications

(154 citation statements)

References 112 publications

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“…The coating mechanism remains to be elucidated at this moment, but we believe that there would be intimate and strong interactions between PG and cell surfaces that precede the PG coating in the isotonic solution. It has been suggested that the plant (poly)phenol deposition, including PG, involves deprotonation and autooxidation, but it does not account for the fact that the PG coating of cells occurs in the isotonic solution. In addition, we observed that the coating speed apparently depended upon the cell types.…”

Section: Figurementioning

confidence: 99%

Artificial Spores: Cytocompatible Coating of Living Cells with Plant‐Derived Pyrogallol

Kim

Lee

Park

et al. 2016

Chemistry An Asian Journal

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Cell nanoencapsulation, generating cell-in-shell structures ("artificial spores"), provides a chemical toolbox for controlling the cellular behaviors and functional characteristics of individual cells. Among the shell materials studied so far, naturally occurring polyphenolic compounds, including polydopamine and tannic acid, have intensively been employed in cell-surface engineering, because their material-independent coating property eliminates an extra priming step for inducing subsequent shell formation. Albeit successful in generating cell-in-shell structures, the coating of polyphenolic compounds generally requires alkaline conditions and/or high salt conditions, which are not compatible with certain cell types. In this work, we demonstrate that the nanocoating of individual cells with a plant-derived phenolic compound, pyrogallol (1,2,3-trihydroxybenzene), occurs at mildly alkaline pH of 7.8 in an isotonic buffer. Three different cell types (anucleate, microbial, and mammalian cells) are coated with pyrogallol without noticeable decrease in cell viability. The protocol developed in this work could be applied to other polyphenolic compounds, and, considering the many polyphenols identified as a coating material, provides an advanced chemical tool in cell-surface engineering.

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Section: Figurementioning

confidence: 99%

Artificial Spores: Cytocompatible Coating of Living Cells with Plant‐Derived Pyrogallol

Kim

Lee

Park

et al. 2016

Chemistry An Asian Journal

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“…This reduction outweighs the entropic cost of the conformational change, which also thermodynamically favors protein adsorption onto ah ydrophobic material surface. [5] To dynamically control material surfaces/interface properties, some stimuli-responsive molecules have been introduced as "smart" coatingsa nd the resultinginterfacial properties couldbetuned by external stimuli. [4] This concept describes which surfaces can promote protein adsorptiond epending on their hydrophobic or hydrophilic properties.…”

Section: Introductionmentioning

confidence: 99%

Photoregulating Antifouling and Bioadhesion Functional Coating Surface Based on Spiropyran

Schlaich

Hou

et al. 2018

Chemistry A European J

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Dynamic regulation of the interactions between specific molecules on functional surfaces and biomolecules, for example, proteins or cells, is critical for biosensor and biomedical devices. Herein, we present a spiropyran (SP)-based light-responsive surface coating, hPG (hyperbranched polyglycerol)-SP, to control the adsorption of proteins and adhesion of cells. In the normal state, the SP groups on the coating surface were in hydrophobic ring-closed form, which promotes the nonspecific protein adsorption and cell adhesion. Under UV irradiation, the grafted SP groups were dynamically isomerized into hydrophilic/zwitterionic merocyanine. Both hydrophilicity and zwitterions support the formation of a hydrated layer and hence the resulting hPG-MC coatings highly resist protein adsorption and cell adhesion. Moreover, the presented hPG also provided a robust bioinert background to suppress the nonspecific protein adsorption and cells adhesion. Therefore, this functionalized coating exhibited a good photoregulated antifouling behavior. Moreover, the detachment of adsorbed proteins and adhered cells from the coating surface was also realized.

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“…In recent years, studies focused on the methods of modification of polymeric membranes have included grafting, coating, and blending . Meanwhile, post‐surface modification methods, such as irradiative chemisorption, physisorption, or bioinspired surface coatings, were developed to functionally modify the chemical activity polymeric membrane matrix, in addition to the chemically inert surface of PVDF . As a type of bleeding method, in situ cross‐linking polymerization is more convenient as its one‐pot procedure.…”

Section: Introductionmentioning

confidence: 99%

“…21 Meanwhile, post-surface modification methods, such as irradiative chemisorption, physisorption, or bioinspired surface coatings, were developed to functionally modify the chemical activity polymeric membrane matrix, in addition to the chemically inert surface of PVDF. 22 As a type of bleeding method, in situ cross-linking polymerization is more convenient as its one-pot procedure. In an in situ crosslinking polymerization process, polymerization and cross-linking occur simultaneously; thus, in situ cross-linking polymerization is a convenient and simple way for large-scale fabrication in industry 23 and has been widely used to design functional materials in the fields of fuel cells, water treatment, stimuli-responsive materials, ion-exchange membranes, and toxins removal.…”

mentioning

confidence: 99%

Improvement in the blood compatibility of polyvinylidene fluoride membranes via in situ cross‐linking polymerization

Nie

Zeng

Qin

et al. 2018

Polymers for Advanced Techs

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In this study, we have provided a highly efficient, convenient, and universal protocol for preparing polyvinylidene fluoride (PVDF) membranes with low blood contact activation via in situ cross‐linking copolymerization of 2‐hydroxyethl methacrylate (HEMA) and acrylic acid (AA) in a solution of PVDF. The modified membranes were prepared from PVDF solution by phase inversion technology. The composition and morphology of the modified membranes were confirmed by attenuated total reflectance‐Fourier transform infrared (ATR‐FTIR) spectroscopy, thermogravimetric (TG) analysis, and scanning electron microscopy (SEM). Protein adsorption, clotting time, and contact activation on the modified PVDF membranes were systematically studied, the results indicating that after the incorporation of AA and HEMA, the modified PVDF membranes possessed anticoagulant properties in addition to low contact activation of blood components when in contact with blood. Therefore, fluorinated PVDF membranes with surfaces enriched with carboxyl and hydroxyl groups possessed the potential for use in long‐term blood‐contacting devices.

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Universal polymer coatings and their representative biomedical applications

Abstract: Universal polymer coatings have excellent potential for biomedical applications, because of their substrate-independent properties and versatile surface functionalization methods.

Cited by 212 publications

References 112 publications

Artificial Spores: Cytocompatible Coating of Living Cells with Plant‐Derived Pyrogallol

Artificial Spores: Cytocompatible Coating of Living Cells with Plant‐Derived Pyrogallol

Photoregulating Antifouling and Bioadhesion Functional Coating Surface Based on Spiropyran

Improvement in the blood compatibility of polyvinylidene fluoride membranes via in situ cross‐linking polymerization

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