Electro-Fenton is a widely used electrochemical advanced oxidation process for the treatment of refractory organic pollutants, in which O 2 input is required to generate hydrogen peroxide. The aeration mode directly affects the dissolution and stability of O 2 bubbles in the solution, thus the rate of degradation. Herein, membrane aeration was introduced to the electro-Fenton degradation of ciprofloxacin in which O 2 was dispersed into the liquid phase in the form of microbubbles through the ceramic membrane. Microbubbles can greatly improve the gas−liquid mass transfer efficiency of unit volume O 2 to obtain an ultrahigh concentration of dissolved O 2 up to 46 mg/L, thus improving the reaction rate. The effects of aeration mode, applied current, membrane aperture, aeration rate, and ciprofloxacin concentration on degradation rate were studied. Compared with the conventional electro-Fenton process using plastic pipe aeration, the membrane aeration-enhanced electro-Fenton (MAEF) system achieved a significant improvement in the degradation rate, and the reaction time required to achieve a 97% degradation ratio was remarkably reduced from 4 h to 10 min. Membrane aeration is an efficient approach to facilitating heterogeneous catalysis reactions involving the gas phase.