Universal leukodepletion of blood components results in a significant reduction of febrile non-hemolytic but not allergic transfusion reactions

Pruß, Axel; Kalus, Ulrich; Radtke, H.; Koscielny, Jürgen; Baumann-Baretti, B.; Balzer, Dominik; Dörner, Thomas; Salama, Abdulgabar; Kiesewetter, H.

doi:10.1016/j.transci.2003.08.013

Cited by 58 publications

(44 citation statements)

References 28 publications

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“…[11] This difference could be attributed to the use of leukodepleted blood components which reduce the incidence of acute nonhemolytic febrile reactions. [12]…”

Section: Discussionmentioning

confidence: 99%

Blood transfusion among thalassemia patients: A single Egyptian center experience

Ragab

Hamdy

Shaheen

et al. 2013

Asian J Transfus Sci

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Background:Although red cell transfusions are lifesavers for patients with thalassemia, they are responsible for a series of complications and expose the patients to a variety of risks.Material and Methods:This cross-sectional study included 464 Egyptian beta(β) thalassemia major patients whose age ranged between 10 months and 31 years (mean 10.2 ± 6.6 years). All patients were subjected to thorough history taking with special emphasis on blood transfusions regarding rate of blood transfusion, type of received blood, and history of previous transfusion reactions in addition to type of chelation and compliance to iron chelation therapy and history of diabetes. Serum ferritin and pretransfusion hemoglobin assessment were done for all patients.Results:The mean pretransfusion hemoglobin level was 5.7 ± 1.16 g/dl. Allergic reactions were observed in 3.9% of the patients during the period of the study, while the history of previous allergic reaction was given by 72% of the patients. Deferiprone showed better compliance (58.6%) than deferoxamine (26.3%). The prevalence of diabetes was 10.1% among the studied group. On comparing diabetics to nondiabetics, serum ferritin, transfusion intervals, and age were statistically higher among diabetics (P<0.001).Conclusion:Lower pretransfusion hemoglobin and high rate of prevalence of diabetes, in addition to better compliance to deferiprone than deferoxamine, were detected among the patients.

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“…[11] This difference could be attributed to the use of leukodepleted blood components which reduce the incidence of acute nonhemolytic febrile reactions. [12]…”

Section: Discussionmentioning

confidence: 99%

Blood transfusion among thalassemia patients: A single Egyptian center experience

Ragab

Hamdy

Shaheen

et al. 2013

Asian J Transfus Sci

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“…Twenty-five % of the patients receiving homologous blood in these studies had allergic reactions with marked loss of plasma volume whereas allergic reactions are nowadays reported to occur at a rate of only 0.03-0.08%. A possible explanation for the decreased incidence of allergic reactions is the introduction of leucocyte-depleted plasma, but other mechanisms have been discussed [14].…”

Section: Discussionmentioning

confidence: 99%

The volume-expanding effects of autologous liquid stored plasma following hemorrhage

Bentzer

Thomas

Westborg

et al. 2012

Scandinavian Journal of Clinical and Laboratory Investigation

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“…The leukodepletion of blood components before they are stored is a prophylactic measure [16][17][18].…”

Section: Non-hemolytic Febrile Transfusion Reactionmentioning

confidence: 99%

Transfusion reaction and hemovigilance: An imperative discussion in Brazilian hemotherapy services

Santos

Alzamora²,

Teles³

et al. 2017

int arch med

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Transfusion of blood components is considered safer, but it took years to reach this level. One of the most effective ways to make blood transfusion a safer practice is hemovigilance, which provides important data, including the history of feared transfusion reactions. In recent years in Brazil, there has been an improvement in the reporting of transfusion reactions, however due to the great diversity of hematology services, there are still transfusion reactions. The aims of this study were described the main types of transfusion reactions, as well as to evaluate the underreporting importance of transfusion occurrences of hemotherapy services in Brazil.

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Universal leukodepletion of blood components results in a significant reduction of febrile non-hemolytic but not allergic transfusion reactions

Cited by 58 publications

References 28 publications

Blood transfusion among thalassemia patients: A single Egyptian center experience

Blood transfusion among thalassemia patients: A single Egyptian center experience

The volume-expanding effects of autologous liquid stored plasma following hemorrhage

Transfusion reaction and hemovigilance: An imperative discussion in Brazilian hemotherapy services

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