Universal and High-Speed Zeptomolar Protein Serum Assay with Unprecedented Sensitivity

Zhang, Ze; Yao, Tao; Han, Hongliang; Ma, Zhanfang

doi:10.1021/acs.analchem.2c03949

Cited by 10 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The separation of immunorecognition and signal readout platforms prevented noise interference and biofouling at the electrode interface, and PEG was used to resist the adsorption of non-specific proteins (Figure 3). This biosensor was utilized to detect h-IgG and exhibited a large dynamic range from 1 µg mL −1 to 100 ag mL −1 and an ultralow limit of detection (LOD) 6.31 ag mL −1 (0.04 zeptomoles mL −1 ) [77]. Due to the magnetic beads' contact with the serum rather than the electrode surface, it is also necessary to modify the magnetic beads' surface with anti-fouling materials to avoid the occurrence of non-specific adsorption.…”

Section: Polyethylene Glycol (Peg) and Its Derivativesmentioning

confidence: 99%

Section: Polyethylene Glycol (Peg) and Its Derivativesmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Fouling Strategies of Electrochemical Sensors for Tumor Markers

Song

Han

2023

Sensors

Self Cite

View full text Add to dashboard Cite

The early detection and prognosis of cancers require sensitive and accurate detection methods; with developments in medicine, electrochemical biosensors have been developed that can meet these clinical needs. However, the composition of biological samples represented by serum is complex; when substances undergo non-specific adsorption to an electrode and cause fouling, the sensitivity and accuracy of the electrochemical sensor are affected. In order to reduce the effects of fouling on electrochemical sensors, a variety of anti-fouling materials and methods have been developed, and enormous progress has been made over the past few decades. Herein, the recent advances in anti-fouling materials and strategies for using electrochemical sensors for tumor markers are reviewed; we focus on new anti-fouling methods that separate the immunorecognition and signal readout platforms.

show abstract

Section: Polyethylene Glycol (Peg) and Its Derivativesmentioning

confidence: 99%

Section: Polyethylene Glycol (Peg) and Its Derivativesmentioning

confidence: 99%

Anti-Fouling Strategies of Electrochemical Sensors for Tumor Markers

Song

Han

2023

Sensors

Self Cite

View full text Add to dashboard Cite

show abstract

“…[4][5][6] Hence, precise monitoring for these biomarkers has become pivotal in preventing the deterioration of disease. [7][8][9] Recently, a variety of detection methods, including electrochemical immunoassay, [10][11][12] mass spectrometry immunoassay, 13 fluorescence immunoassay, 14 and electrochemiluminescence immunoassay, 15 have been widely developed for the accurate detection of disease markers. The electrochemical technique, in particular, has attracted considerable interest owing to its advantages, such as wide dynamic range, facile operation, high specificity, prominent sensitivity, and easy miniaturization.…”

Section: Introductionmentioning

confidence: 99%