Universal acoustic flame detection for modified supercritial fluid chromatography

Xia, Zhongpeng; Thurbide, Kevin B.

doi:10.1016/j.chroma.2005.11.027

Cited by 13 publications

(14 citation statements)

References 26 publications

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“…As a result, the acoustic flame detector (AFD) increases its pitch frequency as a function of the carbon content of the molecule. Thus, in this way the AFD has been found to provide a uniform response toward hydrocarbons that is qualitatively similar to an FID, but with a sensitivity and linear range that is typically at par with an ELSD [29,30].…”

Section: Introductionmentioning

confidence: 94%

“…For instance, its simple and inexpensive design resembles an FID and can be readily adapted to a conventional FID detector base [29,30]. Most significantly however, unlike an FID, the AFD response toward analyte carbon content is not obscured by a modified SC-CO 2 mobile phase [30].…”

Section: Introductionmentioning

confidence: 99%

“…In comparison, the FID signal for 50 lg of anthracene (l47 lg of carbon) is undetectable when using only 1% methanol in SC-CO 2 . Thus, although it is less sensitive than an FID, the AFD can still be a potentially useful alternative universal detector for SFC applications that require organic modifiers but are unable to use an FID [29,30].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, we introduced a novel universal detector for use in LC and SFC that involves measuring the frequency of acoustic emissions from an oscillating hydrogen/oxygen flame [29,30]. The device is based upon the inner cone of the flame partially retreating downward into a capillary delivering a steady upward flow of premixed flame gases.…”

Section: Introductionmentioning

confidence: 99%

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gAn improved interface for universal acoustic flame detection in modified supercritical fluid chromatography

Mah¹,

Thurbide²

2008

J of Separation Science

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An improved interface for universal acoustic flame detection in modified supercritical fluid chromatography A novel method of interfacing the acoustic flame detector (AFD) with modified supercritical fluid chromatography (SFC) is presented. By applying resistive heating directly to the burner region between the restrictor outlet and the acoustic flame, infrequent severe noise, baseline drifting, and peak deformations that can occasionally be observed with the AFD are eliminated. For example, by increasing the interface temperature only a few hundred degrees Celsius, such sporadic noise in the detector can be reduced nearly ten-fold resulting in smooth stable operation of the AFD. Further, for various levels of methanol modified supercritical carbon dioxide mobile phase examined, the interface was observed to reduce detector noise in each to a common minimal range near 10 -25 Hz when an appropriate temperature was achieved. The method is simply assembled, inexpensive to construct, and robust in its daily operation. Overall, the heated interface developed and presented facilitates reliable AFD operation in modified SFC, and supports further exploration and implementation of this sensor as an alternative universal detector in separations requiring an organic cosolvent in the mobile phase.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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gAn improved interface for universal acoustic flame detection in modified supercritical fluid chromatography

Mah¹,

Thurbide²

2008

J of Separation Science

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“…They then showed that the AFD could also be used i 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.jss-journal.com in LC [65] and supercritical fluid chromatography [66] where an organic mobile phase was employed. Since the AFD can "null out" the background response toward carbon in the solvent (i. e., by adjusting the flame conditions), the detector can be used to detect carbon analytes within carbon-containing mobile phases.…”

Section: Acoustic Flame Detection (Afd)mentioning

confidence: 99%

Acoustic methods of detection in gas chromatography

Mah¹,

Thurbide²

2006

J of Separation Science

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Review Acoustic methods of detection in gas chromatographyA brief review of the use of acoustic detection methods in GC is presented. While a number of methods (some quite similar) have been developed for use as gas-phase sensors in various applications, this article focuses specifically on those techniques that have been used to detect analytes following their separation by GC. Overall, a number of "active" acoustic methods (which measure analytes through their interaction with a controlled external acoustic wave source) were reportedly used as GC detectors. These include ultrasonic, thickness shear mode, surface acoustic wave (SAW), and flexural plate wave methods. Conversely, "passive" acoustic methods (those that produce an acoustic signal through some chemical reaction with the analyte) have also been used as GC detectors. These include photoacoustic and acoustic flame methods of detection. Of the two major classifications, reports of active methods are far more prevalent. In particular, the usage of SAW techniques with GC is an area of research that has seen accelerated growth in recent years.

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Detection in Packed Column SFC

2019

Modern Supercritical Fluid Chromatography

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Universal acoustic flame detection for modified supercritial fluid chromatography

Cited by 13 publications

References 26 publications

gAn improved interface for universal acoustic flame detection in modified supercritical fluid chromatography

gAn improved interface for universal acoustic flame detection in modified supercritical fluid chromatography

Acoustic methods of detection in gas chromatography

Detection in Packed Column SFC

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